Pregnancy presents a unique clinical scenario where the safety of pharmacological interventions is of paramount importance. The potential teratogenic risks associated with drug intake during pregnancy necessitate a highly informed, evidence-based approach to prescribing. However, the rapid increase in published literature, clinical trials, and drug safety communications poses significant challenges for clinicians attempting to stay current with evolving data. To address this, we propose an AI-po...

Artificial Intelligence  Simulation/Analytical Evaluation of Communication Systems 

Neuroleptic Malignant Syndrome (NMS) and anticholinergic toxicity are two different but clinically similar disorders that are commonly seen in neuropsychiatric and emergency toxicological settings. Rapid differential diagnosis is made more difficult by the symptoms of both disorders, which frequently include delirium, heat, and autonomic instability. Interventions that result from misidentification may be detrimental or ineffectual. Using a machine learning-driven methodology, this work attempts...

Artificial Intelligence  Psychiatry & Psychology  Drugs & Devices  Diagnostics 

Elderly individuals undergoing long-term neuroleptic therapy are increasingly vulnerable to cognitive decline, a condition that significantly impairs quality of life and increases healthcare burden. One contributing factor is the cumulative anticholinergic burden from prescribed antipsychotic medications. This study aims to explore the relationship between anticholinergic load and cognitive impairment in aging patients using an interpretable machine learning framework. We developed a synthetic d...

Psychiatry & Psychology 

Managing psychiatric disorders, including depression, anxiety, and bipolar disorder, during pregnancy presents significant clinical challenges due to uncertainties surrounding medication safety and efficacy for both the mother and fetus. This study introduces a novel deep learning (DL)-based decision-support framework aimed at personalizing pharmacotherapy for pregnant patients diagnosed with psychiatric conditions. By leveraging electronic health records (EHRs), pharmacogenomic data, and advanc...

Psychiatry & Psychology 

Introduction: Pregnancy-induced hypertension (PIH) is a significant cause of morbidity and mortality among expectant mothers. While some women may be unaware of its existence, others hold misconceptions about its nature or attribute symptoms to superstitions. This study aimed to assess the prevalence, risk factors, and complications of pregnancy-related hypertension among women at Tamale Teaching Hospital. Methods: This cross-sectional study utilized hospital re...

Gynecology & Obstetrics 

Despite Parkinson’s Disease (PD) typically being diagnosed after 80% of dopaminergic neurons are lost, evidence suggests that many patients exhibit early symptoms and frequently utilize emergency department (ED) services years before formal diagnosis. Here we examine the untapped potential of EDs in early PD recognition and intervention. Analysis of nearly 14,000 PD patients from two major healthcare systems revealed that 74% visited the ED or urgent care in the two years preceding diagnosis, ye...

Public Health  Emergency & Critical Care  Neurology 

The relationship between chance and determinism has been analyzed by philosophy, mathematics, and physics. With the aim of identifying the intersection between the two, the Law of Probability Equilibrium (LPE) was demonstrated. When the probabilities of natural phenomena differ from zero and one, the LPE shows that the observed probability is empirical and that the cumulative probability functions of these phenomena measure the imminence of their occurrence (“energy concentration”). These functi...

Atomic Physics 

Employees increasingly use social media to showcase achievements, but this self-presentation may unintentionally provoke envy among peers. While past studies have examined workplace envy in offline settings, little research explores how active self-promotion (e.g., posting accomplishments) and passive browsing (e.g., viewing others’ posts) on platforms like LinkedIn, Face-book, or Instagram contribute to envy. Additionally, the role of workplace friendships in reducing this effect remains unclea...

Business Management  Business Communication  Business Analysis 

The advent of the internet, as we all know, has brought about a significant change in human interaction and business operations around the world; yet, this evolution has also been marked by security issues, including phishing attacks that represent one of the biggest problems to internet users, leading to financial loss and identity theft. The ability of Machine learning and ensemble learning models to process large datasets and complex relationships, and to learn from data have made it easier t...

Network Modeling and Simulation 

Biliary acute pancreatitis (BAP) is a frequent and potentially severe condition requiring appropriate and timely management to reduce complications and recurrence. This study reviews the clinical characteristics and therapeutic approaches to BAP, with a particular focus on the timing of cholecystectomy. The analysis highlights a discrepancy between current international guidelines, which recommend performing cholecystectomy during the same hospitalization, and real-life practices in a regional h...

Gastroenterology & Hepatology