Bipolar disorder is a multifaceted psychiatric illness characterized by unpredictable mood episodes and highly variable treatment responses across individuals. Predicting response to specific pharmacological treatments remains a key challenge in personalized psychiatry. This study aims to develop predictive models for treatment response subtypes—non-responders, lithium responders, and anticonvulsant responders—using a diverse array of biomarkers, including genetic variants, serum levels, neuroim...

Psychiatry & Psychology  Machine Learning 

Bipolar disorder is a complex psychiatric condition characterized by high variability in treatment response, posing a major challenge for clinicians striving to personalize care. Traditional machine learning models often require centralized data access, which is typically restricted in healthcare settings due to privacy regulations and institutional barriers. To address this, we propose a Federated Learning (FL) framework that enables collaborative model training across multiple institutions wit...

Artificial Intelligence  Psychiatry & Psychology 

In today’s world, interaction is inevitable, and diplomacy is one of the most important tools for achieving it. The aim of this article is to examine the role of diplomacy in strengthening international security, explain the distinctive features and indicators of the JCPOA (nuclear) diplomacy in comparison with other diplomatic approaches, and assess the outcomes and achievements of JCPOA diplomacy in the development and establishment of international security. This article seeks to answer the q...

Politics 

Child marriage, a severe human rights violation affecting 23% of girls in Kenya’s pastoralist communities denying girls education, health, and autonomy, perpetuating poverty and gender inequality [1]. Socio-cultural factors like patriarchal norms, bride price, beading, and religious beliefs drive this practice, yet their specific roles remain understudied [2]. Weak legal enforcement exacerbates the issue, necessitating urgent research to identify these perpetuating factors for targeted intervent...

Culture 

In the new era of booming all-for-one tourism development, tourism has increasingly become a key industry related to people’s well-being. People put forward higher requirements for the equalization, comfort and convenience of tourism public services. Efficient supply of tourism public services is the internal requirement for tourism to enhance its core competitiveness and industry vitality, and it is also an inevitable choice for the development of global tourism. This paper uses DEA model, take...

Sociology 

Henry James’s novella “The Turn of the Screw” is marked by its powerful narrative techniques and suspenseful artistry, which imbue the text with ambiguity and contradiction. The mental health of the female teacher and the existence of the ghost have been subjects of ongoing debate among scholars for over a century. While the interpretation of the text is diverse, an analysis from a narrative perspective reveals that part of the controversy stems from three key transformations in the narrative me...

Literature 

Introduction: The aim of this study was to identify the determinants of the occurrence of self-reported sexually transmitted infections (STIs) among adolescent girls in the city of Goma. Methodology: This is an analytical cross-sectional study covering the period from January 5, 2024 to April 5, 2025, i.e., 1 year and 3 months in the city of Goma. During this same period, we took the opportunity to determine the prevalence of STIs in the city of Goma. Of the 388 adolescent girls surveyed in the ...

Gynecology & Obstetrics 

Land is a fundamental resource in the development process, especially in developing countries where land based extractive activities are the main basis of livelihoods in the rural areas. Land tenure is defined as a system of rights and institutions that govern ownership, access and use of land is critical in determining agricultural productivity and management of land-based resources. Understanding tenure systems and their effect on agricultural production is important in any country’s efforts t...

Geography 

The main objective of this study was to examine tourist satisfaction with selected elements of the gastronomic offer in the city of Split. Satisfaction is increasingly becoming the core reason why tourists choose certain destinations, especially as global tourism shifts from sightseeing to experience-based travel. Gastronomy, once perceived merely as a complementary element of the tourist experience, now serves as a strategic factor in destination branding, emotional engagement, and loyalty buil...

Business Management  Marketing  Business Analysis 

In this paper, our purpose is to establish a common fixed point result for a pair of self mappings satisfying some generalized contraction type conditions involving altering distance and control function with two variables in partial metric spaces. Moreover, we provide an example in support of our main result.

Mathematics  Functional Analysis