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Arthritis Research & Therapy

ISSN Print: 1478-6354

ISSN Online:

主页: http://arthritis-research.com

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Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts

Shingo Nakayamada, Hitoshi Kurose, Kazuyoshi Saito, Akira Mogami, Yoshiya Tanaka

Correction: Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis

Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishioka

Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes

Hang-Korng Ea, Benjamin Uzan, Christian Rey, Frédéric Lioté

DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment

Bert Vander Cruyssen, Stijn Van Looy, Bart Wyns, Rene Westhovens, Patrick Durez, Filip Van den Bosch, Eric M Veys, Herman Mielants, Luc De Clerck, Anne Peretz, Michel Malaise, Leon Verbruggen, Nathan Vastesaeger, Anja Geldhof, Luc Boullart, Filip De Keyser

Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats

Atsushi Omoto, Yutaka Kawahito, Igor Prudovsky, Yasunori Tubouchi, Mizuho Kimura, Hidetaka Ishino, Makoto Wada, Makie Yoshida, Masataka Kohno, Rikio Yoshimura, Toshikazu Yoshikawa, Hajime Sano

A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat

James C Keith, Irma M Sainz, Irma Isordia-Salas, Robin A Pixley, Yelena Leathurby, Leo M Albert, Robert W Colman

Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

John Dulos, Allard Kaptein, Annemieke Kavelaars, Cobi Heijnen, Annemieke Boots

Open label phase II trial of single, ascending doses of MRA in Caucasian children with severe systemic juvenile idiopathic arthritis: proof of principle of the efficacy of IL-6 receptor blockade in this type of arthritis and demonstration of prolonged clinical improvement

Patricia Woo, Nicholas Wilkinson, Anne-Marie Prieur, Taunton Southwood, Valentina Leone, Polly Livermore, Helena Wythe, David Thomson, Tadamitsu Kishimoto

Switching TNF antagonists in patients with chronic arthritis: an observational study of 488 patients over a four-year period

Juan J Gomez-Reino, Loreto Carmona, the BIOBADASER Group

Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells

Kyoko Wakamatsu, Toshihiro Nanki, Nobuyuki Miyasaka, Kazuo Umezawa, Tetsuo Kubota

Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity

EN Blaney Davidson, A Scharstuhl, EL Vitters, PM van der Kraan, WB van den Berg

Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes

Jean-Pierre Raynauld, Johanne Martel-Pelletier, Marie-Josée Berthiaume, Gilles Beaudoin, Denis Choquette, Boulos Haraoui, Hyman Tannenbaum, Joan M Meyer, John F Beary, Gary A Cline, Jean-Pierre Pelletier

Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations

Paola Margutti, Maurizio Sorice, Fabrizio Conti, Federica Delunardo, Mauro Racaniello, Cristiano Alessandri, Alessandra Siracusano, Rachele Riganò, Elisabetta Profumo, Guido Valesini, Elena Ortona

Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis

Allan A Young, Margaret M Smith, Susan M Smith, Martin A Cake, Peter Ghosh, Richard A Read, James Melrose, David H Sonnabend, Peter J Roughley, Christopher B Little

Osteoporosis in experimental postmenopausal polyarthritis: the relative contributions of estrogen deficiency and inflammation

Caroline Jochems, Ulrika Islander, Malin Erlandsson, Margareta Verdrengh, Claes Ohlsson, Hans Carlsten

Tumour necrosis factor activates the mitogen-activated protein kinases p38α and ERK in the synovial membrane in vivo

Birgit G？rtz, Silvia Hayer, Birgit Tuerck, Jochen Zwerina, Josef S Smolen, Georg Schett

Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids

R Andrew Moore, Henry J McQuay

Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor

Sofia Ernestam, Erik af Klint, Anca Catrina, Erik Sundberg, Marianne Engstr？m, Lars Klareskog, Ann-Kristin Ulfgren

PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease

Martin Johansson, Lisbeth ？rlestig, G？ran Hallmans, Solbritt Rantap？？-Dahlqvist

Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases

Sharon M Wahl, Wanjun Chen

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

David A Young, Rachel L Lakey, Caroline J Pennington, Debra Jones, Lara Kevorkian, Dylan R Edwards, Timothy E Cawston, Ian M Clark

No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sj？gren's syndrome

Jacques-Eric Gottenberg, Jérémie Sellam, Marc Ittah, Frédéric Lavie, Alexis Proust, Habib Zouali, Christelle Sordet, Jean Sibilia, Robert P Kimberly, Xavier Mariette, Corinne Miceli-Richard

Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis

Jennifer M Milner, Lara Kevorkian, David A Young, Debra Jones, Robin Wait, Simon T Donell, Emma Barksby, Angela M Patterson, Jim Middleton, Benjamin F Cravatt, Ian M Clark, Andrew D Rowan, Timothy E Cawston

The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function

Bernhard M Kirsch, Maximilian Zeyda, Karl Stuhlmeier, Johannes Grisar, Josef S Smolen, Bruno Watschinger, Thomas M Stulnig, Walter H H？rl, Gerhard J Zlabinger, Marcus D S？emann

Synovial histopathology of psoriatic arthritis, both oligo- and polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis

Elli Kruithof, Dominique Baeten, Leen De Rycke, Bernard Vandooren, Dirk Foell, Johannes Roth, Juan D Ca？ete, Annemieke M Boots, Eric M Veys, Filip De Keyser

Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal?

Hans C Nossent, Ole Rekvig

Pathogenesis of rheumatoid arthritis: how early is early?

Gary S Firestein

Reconstitution of the adult B cell repertoire after treatment with rituximab

I？aki Sanz, Jennifer Anolik

Contrasting effects of peroxisome-proliferator-activated receptor (PPAR)γ agonists on membrane-associated prostaglandin E2 synthase-1 in IL-1β-stimulated rat chondrocytes: evidence for PPARγ-independent inhibition by 15-deoxy-Δ12,14prostaglandin J2

Arnaud Bianchi, David Moulin, Sylvie Sebillaud, Meriem Koufany, Marie-Madeleine Galteau, Patrick Netter, Bernard Terlain, Jean-Yves Jouzeau

Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase

Robert Bockermann, David Schubert, Thomas Kamradt, Rikard Holmdahl

Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis

Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato, Kusuki Nishioka

Cold hands – strained heart? Advances in the management of Raynaud's phenomenon and pulmonary hypertension

Frances C Hall

Dynamic magnetic resonance of the wrist in psoriatic arthritis reveals imaging patterns similar to those of rheumatoid arthritis

Marco A Cimmino, Massimiliano Parodi, Stefania Innocenti, Giulia Succio, Simone Banderali, Enzo Silvestri, Giacomo Garlaschi

Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis

S Guiducci, A Del Rosso, M Cinelli, F Perfetto, R Livi, A Rossi, A Gabrielli, R Giacomelli, N Iori, G Fibbi, M Del Rosso, M Matucci Cerinic

Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis

Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama, Yasunori Okada

Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis?

Aleksi Sedo, Jonathan S Duke-Cohan, Eva Balaziova, Liliana R Sedova

Clinical and laboratory characteristics of drug-induced vasculitic syndromes

Allan Wiik

Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy

Takako Miyamae, David E Malehorn, Bonnie Lemster, Masaaki Mori, Tomoyuki Imagawa, Shumpei Yokota, William L Bigbee, Manda Welsh, Klaus Klarskov, Norihiro Nishomoto, Abbe N Vallejo, Raphael Hirsch

Peripheral blood but not synovial fluid natural killer T cells are biased towards a Th1-like phenotype in rheumatoid arthritis

Loes Linsen, Marielle Thewissen, Kurt Baeten, Veerle Somers, Piet Geusens, Jef Raus, Piet Stinissen

Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

Vineeth S Rajkumar, Kevin Howell, Katalin Csiszar, Christopher P Denton, Carol M Black, David J Abraham

Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: comparison with idiopathic ANCA vasculitides

Branka Bonaci-Nikolic, Milos M Nikolic, Sladjana Andrejevic, Svetlana Zoric, Mirjana Bukilica

Modeling human arthritic diseases in nonhuman primates

Michel PM Vierboom, Margreet Jonker, Ronald E Bontrop, Bert 't Hart

Aerobic exercise and its impact on musculoskeletal pain in older adults: a 14 year prospective, longitudinal study

Bonnie Bruce, James F Fries, Deborah P Lubeck

Accelerated development of arthritis in mice lacking endothelial selectins

Jeffrey H Ruth, M Asif Amin, James M Woods, Xiaodong He, Sharon Samuel, Nengjun Yi, Christian S Haas, Alisa E Koch, Daniel C Bullard

Histone deacetylases – a new target for suppression of cartilage degradation?

John S Mort

Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1)

Marion Hückel, Uta Schurigt, Andreas H Wagner, Renate St？ckigt, Peter K Petrow, Klaus Thoss, Mieczyslaw Gajda, Steffen Henzgen, Markus Hecker, Rolf Br？uer

The PI3K–NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis

Pnina Fishman, Sara Bar-Yehuda, Lea Madi, Lea Rath-Wolfson, Avivit Ochaion, Shira Cohen, Ehud Baharav

Gastrin-releasing peptide, substance P and cytokines in rheumatoid arthritis

Paul G Green

Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada

Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis

Sarah L Jongbloed, M Cristina Lebre, Alasdair R Fraser, J Alastair Gracie, Roger D Sturrock, Paul P Tak, Iain B McInnes

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