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Trials

ISSN Print: 1745-6215

ISSN Online:

主页: http://www.trialsjournal.com

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Duty, desire or indifference? A qualitative study of patient decisions about recruitment to an epilepsy treatment trial

Krysia Canvin, Ann Jacoby

Selecting patients for randomized trials: a systematic approach based on risk group

Andrew J Vickers, Barry S Kramer, Stuart G Baker

Hemicraniectomy after middle cerebral artery infarction with life-threatening Edema trial (HAMLET). Protocol for a randomised controlled trial of decompressive surgery in space-occupying hemispheric infarction

Jeannette Hofmeijer, G Johan Amelink, Ale Algra, Jan van Gijn, Malcolm R Macleod, L Jaap Kappelle, H Bart van der Worp, the HAMLET investigators

A randomized, double blind, cross-over, placebo-controlled clinical trial to assess the effects of Candesartan on the insulin sensitivity on non diabetic, non hypertense subjects with dysglyce mia and abdominal obesity. "ARAMIA"

Patricio López-Jaramillo, Lina P Pradilla, Vicente Lahera, Federico Sieger, Christian F Rueda-Clausen, Gustavo A Márquez

Protocol design and current status of CLIVIT: a randomized controlled multicenter relevance trial comparing clips versus ligatures in thyroid surgery

CM Seiler, BE Fr？hlich, JA Veit, E Gazyakan, MN Wente, C Wollermann, A Deckert, S Witte, N Victor, MW Buchler, HP Knaebel

Factors associated with compliance and non-compliance by physicians in a large-scale randomized clinical trial

Koji Oba, Satoshi Morita, Mahbubur Rahman, Junichi Sakamoto

Double blind randomized placebo-controlled trial on the effects of testosterone supplementation in elderly men with moderate to low testosterone levels: design and baseline characteristics [ISRCTN23688581]

Hamid Reza Nakhai Pour, Marielle H Emmelot-Vonk, Marja Sukel-Helleman, Harald JJ Verhaar, Diederick E Grobbee, Yvonne T van der Schouw

Will availability of inhaled human insulin (Exubera？) improve management of type 2 diabetes? The design of the Real World trial

Nick Freemantle, Thomas R Strack, the Real World Trialists

CHARITY: Chagas cardiomyopathy bisoprolol intervention study: a randomized double-blind placebo force-titration controlled study with Bisoprolol in patients with chronic heart failure secondary to Chagas cardiomyopathy [NCT00323973]

Franklin R Quiros, Carlos A Morillo, Juan P Casas, Luz A Cubillos, Federico A Silva

Sub-vastus approach versus the medial parapatellar approach in primary total knee: a randomised controlled trial [ISRCTN44544446]

Stephen Bridgman, Gayle Walley, Gilbert MacKenzie, Darren Clement, David Griffiths, Nicola Maffulli

A randomized clinical trial of unfractioned heparin for treatment of sepsis (the HETRASE study): design and rationale [NCT00100308]

Fabián Jaimes, Gisela De La Rosa, Clara Arango, Fernando Fortich, Carlos Morales, Daniel Aguirre, Pablo Pati？o

Comparison of Venae Sectio vs. modified Seldinger Technique for Totally Implantable Access Ports; Portas-trial [ISRCTN:52368201]

P Knebel, B Fr？hlich, H-P Knaebel, P Kienle, S Luntz, MW Buchler, CM Seiler

Lessons and implications from a mass immunization campaign in squatter settlements of Karachi, Pakistan: an experience from a cluster-randomized double-blinded vaccine trial [NCT00125047]

Mohammad Khan, Rion Ochiai, Hasan Hamza, Shah Sahito, Muhammad Habib, Sajid Soofi, Naveed Bhutto, Shahid Rasool, Mahesh K Puri, Mohammad Ali, Shafi Wasan, Mohammad Khan, Remon Abu-Elyazeed, Bernard Ivanoff, Claudia M Galindo, Tikki Pang, Allan Donner, Lorenz von Seidlein, Camilo J Acosta, John D Clemens, Shaikh Nizami, Zulfiqar A Bhutta

1Design of the Primary Prevention Parameters Evaluation (PREPARE) trial of implantablecardioverter defibrillators to reduce patient morbidity [NCT00279279]

Bruce L Wilkoff, Richard Stern, Brian Williamson, Mark Wathen, Keith Holloman, Ann Fieberg, Mark Brown

Whose data set is it anyway? Sharing raw data from randomized trials

Andrew J Vickers

Double blind, randomized controlled trial, to evaluate the effectiveness of a controlled nitric oxide releasing patch versus meglumine antimoniate in the treatment of cutaneous leishmaniasis [NCT00317629]

Sandra Y Silva, Ligia C Rueda, Marcos López, Iván D Vélez, Christian F Rueda-Clausen, Daniel J Smith, Gerardo Mu？oz, Hernando Mosquera, Federico A Silva, Adriana Buitrago, Holger Díaz, Patricio López-Jaramillo

Duodenum preserving pancreatectomy in chronic pancreatitis: Design of a randomized controlled trial comparing two surgical techniques [ISRCTN50638764]

J？rg K？ninger, Christoph M Seiler, Moritz N Wente, Margot A Reidel, Emre Gazyakan, Ulrich Mansmann, Michael W Müller, Helmut Friess, Markus W Büchler

Issues of informed consent for intrapartum trials: a suggested consent pathway from the experience of the Release trial [ISRCTN13204258]

Gillian Vernon, Zarko Alfirevic, Andrew Weeks

The effects of organic nitrates on osteoporosis: a randomized controlled trial [ISRCTN94484747]

Sophie A Jamal, Celeste J Hamilton, Dennis Black, Steven R Cummings

Prophylactic antibiotic for prevention of posttraumatic meningitis after traumatic pneumocephalus: design and rationale of a placebo-controlled randomized multicenter trial [ISRCTN71132784]

Behzad Eftekhar, Mohammad Ghodsi, Azar Hadadi, Mousa Taghipoor, Samira Sigarchi, Vafa Rahimi-Movaghar, Ehsan Kazemzadeh, Babak Esmaeeli, Farideh Nejat, Alireza Yalda, Ebrahim Ketabchi

The internal thoracic artery skeletonization study: A paired, within-patient comparison [NCT00265499]

Munir Boodhwani, Howard J Nathan, B Khanh Lam, Fraser D Rubens

Flaws in design, analysis and interpretation of Pfizer's antifungal trials of voriconazole and uncritical subsequent quotations

Karsten J J？rgensen, Helle Johansen, Peter C G？tzsche

Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265]

David P Taggart, Belinda Lees, Alastair Gray, Douglas G Altman, Marcus Flather, Keith Channon, the ART Investigators

Lead editorial: Trials – using the opportunities of electronic publishing to improve the reporting of randomised trials

Douglas G Altman, Curt D Furberg, Jeremy M Grimshaw, Peter M Rothwell

Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study

Claire Snowdon, Diana R Elbourne, Jo Garcia, Marion K Campbell, Vikki A Entwistle, David Francis, Adrian M Grant, Rosemary C Knight, Alison M McDonald, Ian Roberts

Comparison of the efficacy and safety of rosuvastatin 10 mg and atorvastatin 20 mg in high-risk patients with hypercholesterolemia – Prospective study to evaluate the Use of Low doses of the Statins Atorvastatin and Rosuvastatin (PULSAR)

Michael B Clearfield, John Amerena, Jean-Pierre Bassand, Hugo García, Sam S Miller, Froukje FM Sosef, Michael K Palmer, Brian S Bryzinski

Fracture risk and the use of a diuretic (indapamide sr) ± perindopril: a substudy of the Hypertension in the Very Elderly Trial (HYVET)

Christopher J Bulpitt, Ruth Peters, Jan A Staessen, Lutgarde Thijs, Marie-Christine De Vernejoul, Astrid E Fletcher, Nigel S Beckett

Multifactorial day hospital intervention to reduce falls in high risk older people in primary care: a multi-centre randomised controlled trial [ISRCTN46584556]

Tahir Masud, Carol Coupland, Avril Drummond, John Gladman, Denise Kendrick, Tracey Sach, Rowan Harwood, Pradeep Kumar, Rob Morris, Rachael Taylor, Jane Youde, Simon Conroy

Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners. Design of The MASTERPLAN Study [ISRCTN73187232]

Arjan D van Zuilen, Ingeborgh van der Tweel, Peter J Blankestijn, Michiel L Bots, Marjolijn van Buren, Marc AGJ ten Dam, Karin AH Kaasjager, Peter JG van de Ven, Gerald Vervoort, Louis-Jean Vleming, Gerry Ligtenberg, Jack FM Wetzels, the MASTERPLAN study group

What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies

Alison M McDonald, Rosemary C Knight, Marion K Campbell, Vikki A Entwistle, Adrian M Grant, Jonathan A Cook, Diana R Elbourne, David Francis, Jo Garcia, Ian Roberts, Claire Snowdon

Protocol for the 'e-Nudge trial': a randomised controlled trial of electronic feedback to reduce the cardiovascular risk of individuals in general practice [ISRCTN64828380]

Tim A Holt, Margaret Thorogood, Frances Griffiths, Stephen Munday

Increasing participation of cancer patients in randomised controlled trials: a systematic review

Catriona Mc Daid, Zoé Hodges, Debra Fayter, Lisa Stirk, Alison Eastwood

CRASH2 in Germany [ISRCTN86750102]

CH Chung, A Freiberger, M Kalkum, SP Luntz, H Shakur, CM Seiler

A multi-centre randomized controlled trial comparing electrothermal arthroscopic capsulorrhaphy versus open inferior capsular shift for patients with shoulder instability: Protocol implementation and interim performance: Lessons learned from conducting a multi-centre RCT [ISRCTN68224911; NCT00251160]

NG Mohtadi, RM Hollinshead, PJ Ceponis, DS Chan, GH Fick

Acetylsalicylic acid as an adjuvant therapy for schizophrenia

Wijnand Laan, Jean-Paul Selten, René S Kahn, Anne-Margriet Huisman, Cobi J Heijnen, Diederick E Grobbee, Huibert Burger

The SPHERE Study. Secondary prevention of heart disease in general practice: protocol of a randomised controlled trial of tailored practice and patient care plans with parallel qualitative, economic and policy analyses. [ISRCTN24081411]

Andrew W Murphy, Margaret E Cupples, Susan M Smith, Molly Byrne, Claire Leathem, Mary C Byrne

Enzyme estimates of infarct size correlate with functional and clinical outcomes in the setting of ST-segment elevation myocardial infarction

Aslan T Turer, Kenneth W Mahaffey, Dianne Gallup, W Douglas Weaver, Robert H Christenson, Nathan R Every, E Magnus Ohman

The clopidogrel after surgery for coronary artery disease (CASCADE) randomized controlled trial: clopidogrel and aspirin versus aspirin alone after coronary bypass surgery [NCT00228423]

Alexander Kulik, Michel Le May, George A Wells, Thierry G Mesana, Marc Ruel

Predictors of post-operative mortality following treatment for non-ruptured abdominal aortic aneurysm

Sigitas Urbonavicius, Henrik Vorum, Grazina Urbonaviciene, Mindaugas Trumpickas, Dainius Pavalkis, Bent Honoré

Coronary artery bypass surgery in high-risk patients

Alper Kunt, Osman Darc？n, Mehmet Andac

Symptomatic relief precedes improvement of myocardial blood flow in patients under spinal cord stimulation

Holger Diedrichs, Carsten Zobel, Peter Theissen, Michael Weber, Athanassios Koulousakis, Harald Schicha, Robert HG Schwinger

Beyond the Evidence of the New Hypertension Guidelines. Blood pressure measurement – is it good enough for accurate diagnosis of hypertension? Time might be in, for a paradigm shift (I)

Cornel Pater

Exercise training improves aerobic endurance and musculoskeletal fitness in female cardiac transplant recipients

Mark Haykowsky, Kenneth Riess, Linda Figgures, Daniel Kim, Darren Warburton, Lee Jones, Wayne Tymchak

Effect of increased convective clearance by on-line hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients – the Dutch CONvective TRAnsport STudy (CONTRAST): rationale and design of a randomised controlled trial [ISRCTN38365125]

E Lars Penne, Peter J Blankestijn, Michiel L Bots, Marinus A van den Dorpel, Muriel P Grooteman, Menso J Nubé, Ingeborg van der Tweel, Piet M ter Wee, the CONTRAST study group

Presence of factors that activate platelet aggregation in mitral stenotic patients' plasma

Istemihan Tengiz, Ertugrul Ercan, Fahri Sahin, Emin Alioglu, Can Duman, Guray Saydam, Filiz Buyukkececi

Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors

Mark A Espeland, Daniel H O'Leary, James G Terry, Timothy Morgan, Greg Evans, Harald Mudra

Fluvastatin in the therapy of acute coronary syndrome: Rationale and design of a multicenter, randomized, double-blind, placebo-controlled trial (The FACS Trial)[ISRCTN81331696]

Petr Ostadal, David Alan, Petr Hajek, Jiri Vejvoda, Martin Mates, Peter Blasko, Josef Veselka, Milan Kvapil, Jiri Kettner, Martin Wiendl, Ondrej Aschermann, Josef Slaby, Eduard Nemecek, Frantisek Holm, Marek Rac, Milan Macek, Jana Cepova

The Blood Pressure "Uncertainty Range" – a pragmatic approach to overcome current diagnostic uncertainties (II)

Cornel Pater

Effect of rosuvastatin on outcomes in chronic haemodialysis patients – design and rationale of the AURORA study

Bengt Fellstr？m, Faiez Zannad, Roland Schmieder, Hallvard Holdaas, Alan Jardine, Helen Rose, Wim Wilpshaar, the AURORA Study Group

Combining short stent implantation and drug-eluting stenting for routine use yields a low restenosis rate

Ulrich Dietz, Cheryl Dauer, Heinz Lambertz

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