Why genomics is more than genomes

Jeffrey G Lawrence

Polymerase may be key to flu's virulence

Cathy Holding

GOToolBox: functional analysis of gene datasets based on Gene Ontology

David Martin, Christine Brun, Elisabeth Remy, Pierre Mouren, Denis Thieffry, Bernard Jacq

Comprehensive analysis of pseudogenes in prokaryotes: widespread gene decay and failure of putative horizontally transferred genes

Yang Liu, Paul M Harrison, Victor Kunin, Mark Gerstein

Molecular tumor profiling: translating genomic insights into clinical advances

Alison H Trainer

Articles selected by Faculty of 1000: proteomics of sumoylation; single-molecule sequencing; membrane glycoproteomics; MHC haplotype sequencing; transcriptome evolution

Success for gene therapy: render unto Caesar that which is Caesar's

Jian Qiao, Rosa Diaz, Richard G Vile

Common ground in the transcriptional profiles of wounds and tumors

Richard Grose

NIH research to be open access

Paula Park

Genomic, chromosomal and allelic assessment of the amazing diversity of maize

Virginia Walbot

Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes

Hui Huang, Eitan E Winter, Huajun Wang, Keith G Weinstock, Heming Xing, Leo Goodstadt, Peter D Stenson, David N Cooper, Douglas Smith, M Mar Albà, Chris P Ponting, Kim Fechtel

Detecting DNA regulatory motifs by incorporating positional trends in information content

Katherina J Kechris, Erik van Zwet, Peter J Bickel, Michael B Eisen

Identification of conserved gene structures and carboxy-terminal motifs in the Myb gene family of Arabidopsis and Oryza sativa L. ssp. indica

Cizhong Jiang, Xun Gu, Thomas Peterson

Exploratory differential gene expression analysis in microarray experiments with no or limited replication

Alexander V Loguinov, I Saira Mian, Chris D Vulpe

Extracellular genomic DNA protects mice against radiation and chemical mutagens

Leonid A Yakubov, Nelly A Popova, Valery P Nikolin, Dmitry V Semenov, Sergei S Bogachev, Irina N Oskina

MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins

Sebastian Maurer-Stroh, Masaki Gouda, Maria Novatchkova, Alexander Schleiffer, Georg Schneider, Fernanda L Sirota, Michael Wildpaner, Nobuhiro Hayashi, Frank Eisenhaber

A drop in the bucket

Gregory A Petsko

New function for telomerase?

Graciela Flores

Spatial patterns of transcriptional activity in the chromosome of Escherichia coli

Kyeong Jeong, Jaeyong Ahn, Arkady B Khodursky

Articles selected by Faculty of 1000: high-throughput Arabidopsis metabolomics; mitochondrial DNA nucleoids; behavioral epigenetics; dissecting DNA-binding proteins; chemical genetics of adipogenesis

Development of a method for screening short-lived proteins using green fluorescent protein

Xin Jiang, Philip Coffino, Xianqiang Li

Bioinformatics awarded

Ned Stafford

Worms reveal intron insights

Nicole Johnston

A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults

Michael Parisi, Rachel Nuttall, Pamela Edwards, James Minor, Daniel Naiman, Jining Lü, Michael Doctolero, Marina Vainer, Cathy Chan, James Malley, Scott Eastman, Brian Oliver

Identifying transcriptional targets

Nicola V Taverner, James C Smith, Fiona C Wardle

Olfactory research wins Nobel

Stephen Pincock

Can we find the genes involved in complex traits?

Mathew Pletcher, Tim Wiltshire

The lords of the genomes

Mark Stapleton

Bacteria may have endless diversity

Melissa Phillips

Flies with inner ears?

David Secko

Refining the genome

Cathy Holding

Insects may have complex immunity

Charles Q Choi

Cancer, oncogenes and signal transduction

Edward J McManus, Dario R Alessi

Root genomics: towards digital in situ hybridization

Ben Scheres, Henk van den Toorn, Renze Heidstra

A first-draft human protein-interaction map

Ben Lehner, Andrew G Fraser

Chimps are not like humans

Cathy Holding

A burst of energy in metabolic disease research

Jaswinder K Sethi

RNAi dissects signal pathway

Cathy Holding

Articles selected by Faculty of 1000: marine micro-eukaryote phylogenetics; quantitative proteomics; the tubulin-binding proteome; rooting the tree of life with wobble; sizing protein aggregates

START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors

Kathrin Schrick, Diana Nguyen, Wojciech M Karlowski, Klaus FX Mayer

Bioconductor: open software development for computational biology and bioinformatics

Robert C Gentleman, Vincent J Carey, Douglas M Bates, Ben Bolstad, Marcel Dettling, Sandrine Dudoit, Byron Ellis, Laurent Gautier, Yongchao Ge, Jeff Gentry, Kurt Hornik, Torsten Hothorn, Wolfgang Huber, Stefano Iacus, Rafael Irizarry, Friedrich Leisch, Cheng Li, Martin Maechler, Anthony J Rossini, Gunther Sawitzki, Colin Smith, Gordon Smyth, Luke Tierney, Jean YH Yang, Jianhua Zhang

Chemical genomics in yeast

Charles Brenner

Predicting and validating microRNA targets

Eric C Lai

Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli

Brian J Peter, Javier Arsuaga, Adam M Breier, Arkady B Khodursky, Patrick O Brown, Nicholas R Cozzarelli

Articles selected by Faculty of 1000: phage receptor-binding proteins; genetic diversity in Toxoplasma; ribosome biogenesis and cell size; gene regulation by retrotransposons; manipulation of the cancer epigenome

Plug-n-play in Staph adaptation

Cathy Holding

Articles selected by Faculty of 1000: profiling biofilms and antibiotic responses; seleno proteomics; nitrilases from uncloned genomes; fish comparative morphology and genetics; comparing mass spectrometry algorithms

An overview of the basic helix-loop-helix proteins

Susan Jones

The diversity of LTR retrotransposons

Ericka R Havecker, Xiang Gao, Daniel F Voytas

Recent advances in Drosophila genomics

Melissa B Davis, Kevin P White