Genome Biology - oalib

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ISSN: 2333-9721
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Genome Biology

ISSN Print: 1465-6906

ISSN Online:

主页: http://genomebiology.com

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Reduced reliance on the trace element selenium during evolution of mammals

Alexey V Lobanov, Dolph L Hatfield, Vadim N Gladyshev

Functional protein divergence in the evolution of Homo sapiens

Nuria Lopez-Bigas, Subhajyoti De, Sarah A Teichmann

Anchoring the genome

Diego Ottaviani, Elliott Lever, Petros Takousis, Denise Sheer

Yeast Polo-like kinase substrates are nailed with the right tools

Vincent Archambault, David M Glover

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus

Christoph Welsch, Francisco S Domingues, Simone Susser, Iris Antes, Christoph Hartmann, Gabriele Mayr, Andreas Schlicker, Christoph Sarrazin, Mario Albrecht, Stefan Zeuzem, Thomas Lengauer

Computational discovery of cis-regulatory modules in Drosophila without prior knowledge of motifs

Andra Ivan, Marc S Halfon, Saurabh Sinha

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions

Richard Birnie, Steven D Bryce, Claire Roome, Vincent Dussupt, Alastair Droop, Shona H Lang, Paul A Berry, Catherine F Hyde, John L Lewis, Michael J Stower, Norman J Maitland, Anne T Collins

At-TAX: a whole genome tiling array resource for developmental expression analysis and transcript identification in Arabidopsis thaliana

Sascha Laubinger, Georg Zeller, Stefan R Henz, Timo Sachsenberg, Christian K Widmer, Na？ra Naouar, Marnik Vuylsteke, Bernhard Sch？lkopf, Gunnar R？tsch, Detlef Weigel

Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling

Chandran Vijayendran, Aiko Barsch, Karl Friehs, Karsten Niehaus, Anke Becker, Erwin Flaschel

Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes

Timothy E Cullingford, Thomais Markou, Stephen J Fuller, Alejandro Giraldo, Sampsa Pikkarainen, Georgia Zoumpoulidou, Ali Alsafi, Collins Ekere, Timothy J Kemp, Jayne L Dennis, Laurence Game, Peter H Sugden, Angela Clerk

Functional diversification of duplicate genes through subcellular adaptation of encoded proteins

Ana C Marques, Nicolas Vinckenbosch, David Brawand, Henrik Kaessmann

The Argonaute protein family

Julia H？ck, Gunter Meister

A systems view of Drosophila segmentation

Mike Levine

Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds)

Thomas M Wishart, Helen N Pemberton, Sally R James, Chris J McCabe, Thomas H Gillingwater

Proteomic analysis of the secretome of Leishmania donovani

J Maxwell Silverman, Simon K Chan, Dale P Robinson, Dennis M Dwyer, Devki Nandan, Leonard J Foster, Neil E Reiner

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

Robin Ketteler, Zairen Sun, Karl F Kovacs, Wei-Wu He, Brian Seed

Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments

Karuppasamy Manikandan, Debnath Pal, Suryanarayanarao Ramakumar, Nathan E Brener, Sitharama S Iyengar, Guna Seetharaman

Quantitative methods for genome-scale analysis of in situ hybridization and correlation with microarray data

Chang-Kyu Lee, Susan M Sunkin, Chihchau Kuan, Carol L Thompson, Sayan Pathak, Lydia Ng, Chris Lau, Shanna Fischer, Marty Mortrud, Cliff Slaughterbeck, Allan Jones, Ed Lein, Michael Hawrylycz

Mining physical protein-protein interactions from the literature

Minlie Huang, Shilin Ding, Hongning Wang, Xiaoyan Zhu

Plastic architecture of bacterial genome revealed by comparative genomics of Photorhabdus variants

Sophie Gaudriault, Sylvie Pages, Anne Lanois, Christine Laroui, Corinne Teyssier, Estelle Jumas-Bilak, Alain Givaudan

Inferring mouse gene functions from genomic-scale data using a combined functional network/classification strategy

Wan Kim, Chase Krumpelman, Edward M Marcotte

Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function

Weidong Tian, Lan V Zhang, Murat Ta？an, Francis D Gibbons, Oliver D King, Julie Park, Zeba Wunderlich, J Michael Cherry, Frederick P Roth

A BAC-based integrated linkage map of the silkworm Bombyx mori

Kimiko Yamamoto, Junko Nohata, Keiko Kadono-Okuda, Junko Narukawa, Motoe Sasanuma, Shun-ichi Sasanuma, Hiroshi Minami, Michihiko Shimomura, Yoshitaka Suetsugu, Yutaka Banno, Kazutoyo Osoegawa, Pieter J de Jong, Marian R Goldsmith, Kazuei Mita

Cytoplasmic dynein could be key to understanding neurodegeneration

Gareth T Banks, Elizabeth MC Fisher

Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly

Matthew J Hardman, Gillian S Ashcroft

CpG island density and its correlations with genomic features in mammalian genomes

Leng Han, Bing Su, Wen-Hsiung Li, Zhongming Zhao

The new Manichaeans

Gregory A Petsko

Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice

Jonathan M Mudge, Stuart D Armstrong, Karen McLaren, Robert J Beynon, Jane L Hurst, Christine Nicholson, Duncan H Robertson, Laurens G Wilming, Jennifer L Harrow

Picoeukaryotic sequences in the Sargasso Sea metagenome

Gwenael Piganeau, Yves Desdevises, Evelyne Derelle, Herve Moreau

Analysis of repetitive DNA distribution patterns in the Tribolium castaneum genome

Suzhi Wang, Marcé D Lorenzen, Richard W Beeman, Susan J Brown

Protein interactions in human genetic diseases

Benjamin Schuster-B？ckler, Alex Bateman

In silico meets in vivo

Zhiping Weng, Roderic Guigó

Computational identification of obligatorily autocatalytic replicators embedded in metabolic networks

ádám Kun, Balázs Papp, E？rs Szathmáry

Genome assembly forensics: finding the elusive mis-assembly

Adam M Phillippy, Michael C Schatz, Mihai Pop

Indirect genomic effects on survival from gene expression data

Egil Ferkingstad, Arnoldo Frigessi, Heidi Lyng

Genetic determinants of phenotypic diversity in humans

Nazli G Rahim, Olivier Harismendy, Eric J Topol, Kelly A Frazer

Chromatin organization and expression

Elaine Sanij, Ross D Hannan

Do Alu repeats drive the evolution of the primate transcriptome?

Araxi O Urrutia, Leandro Oca？a, Laurence D Hurst

A role for Numb in p53 stabilization

Stephanie Carter, Karen H Vousden

RNA polymerase II stalling: loading at the start prepares genes for a sprint

Jia Wu, Michael Snyder

Histone deacetylase inhibition accelerates the early events of stem cell differentiation: transcriptomic and epigenetic analysis

Efthimia Karantzali, Herbert Schulz, Oliver Hummel, Norbert Hubner, AK Hatzopoulos, Androniki Kretsovali

Finding exonic islands in a sea of non-coding sequence: splicing related constraints on protein composition and evolution are common in intron-rich genomes

Tobias Warnecke, Joanna L Parmley, Laurence D Hurst

MINT and IntAct contribute to the Second BioCreative challenge: serving the text-mining community with high quality molecular interaction data

Andrew Chatr-aryamontri, Samuel Kerrien, Jyoti Khadake, Sandra Orchard, Arnaud Ceol, Luana Licata, Luisa Castagnoli, Stefano Costa, Cathy Derow, Rachael Huntley, Bruno Aranda, Catherine Leroy, Dave Thorneycroft, Rolf Apweiler, Gianni Cesareni, Henning Hermjakob

The transcriptional program underlying the physiology of clostridial sporulation

Shawn W Jones, Carlos J Paredes, Bryan Tracy, Nathan Cheng, Ryan Sillers, Ryan S Senger, Eleftherios T Papoutsakis

SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays

Miguel A Anton, Dorleta Gorostiaga, Elizabeth Guruceaga, Victor Segura, Pedro Carmona-Saez, Alberto Pascual-Montano, Ruben Pio, Luis M Montuenga, Angel Rubio

Analysis of 142 genes resolves the rapid diversification of the rice genus

Xin-Hui Zou, Fu-Min Zhang, Jian-Guo Zhang, Li-Li Zang, Liang Tang, Jun Wang, Tao Sang, Song Ge

Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast

Roberta Ruotolo, Gessica Marchini, Simone Ottonello

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