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ISSN: 2333-9721
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Molecular Cancer

ISSN Print: 1476-4598

ISSN Online:

主页: http://www.molecular-cancer.com

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Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation

Catherine Gill, Catherine Dowling, Amanda J O'Neill, R William G Watson

Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish

Bensheng Ju, Jan Spitsbergen, Christopher J Eden, Michael R Taylor, Wenbiao Chen

Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects

Alla V Ivanova, Sergey V Ivanov, Ljudmila Prudkin, Daisuke Nonaka, Zhandong Liu, Anne Tsao, Ignacio Wistuba, Jack Roth, Harvey I Pass

EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cells

Prasanthi Karna, Starlette M Sharp, Clayton Yates, Satya Prakash, Ritu Aneja

Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival

Jin-e Yao, Min Yan, Zhong Guan, Chao-bin Pan, Liang-ping Xia, Chuan-xing Li, Li-hui Wang, Zi-jie Long, Yan Zhao, Ming-wei Li, Fei-meng Zheng, Jie Xu, Dong-jun Lin, Quentin Liu

No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue

Ludmila Prokunina-Olsson, Jennifer L Hall

Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression

Aaron E Foster, Fatma V Okur, Ettore Biagi, An Lu, Gianpietro Dotti, Eric Yvon, Barbara Savoldo, George Carrum, Michael Andreeff, Margaret A Goodell, Helen E Heslop, Malcolm K Brenner

Antiproliferative effect of exemestane in lung cancer cells

Angelos Koutras, Efstathia Giannopoulou, Ismini Kritikou, Anna Antonacopoulou, TR Jeffry Evans, Athanasios G Papavassiliou, Haralabos Kalofonos

Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis

Alison K Bauer, Jennifer Fostel, Laura M Degraff, Elizabeth A Rondini, Christopher Walker, Sherry F Grissom, Julie Foley, Steven R Kleeberger

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

Lirong Peng, Xiaofang Xing, Weijun Li, Like Qu, Lin Meng, Shenyi Lian, Beihai Jiang, Jian Wu, Chengchao Shou

Activation of hedgehog signaling is not a frequent event in ovarian cancers

Ling Yang, Jing He, Shuhong Huang, Xiaoli Zhang, Yuehong Bian, Nonggao He, Hongwei Zhang, Jingwu Xie

Dual effects of TGF-β on ERα-mediated estrogenic transcriptional activity in breast cancer

Yongsheng Ren, Liyu Wu, Andra R Frost, William Grizzle, Xu Cao, Mei Wan

Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo

Shuchen Gu, Natalia Papadopoulou, Eva-Maria Gehring, Omaima Nasir, Konstantinos Dimas, Shefalee K Bhavsar, Michael F？ller, Konstantinos Alevizopoulos, Florian Lang, Christos Stournaras

Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3

Bianca R Dias, Elaine G Rodrigues, Leonardo Nimrichter, Ernesto S Nakayasu, Igor C Almeida, Luiz R Travassos

Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions

Caroline N Mills, Sandeep S Joshi, Richard M Niles

Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway

Peixin Dong, Zhujie Xu, Nan Jia, Dajin Li, Youji Feng

Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines

Therese Bredholt, Elizabeth AO Dimba, Hanne R Hagland, Line Wergeland, J？rn Skavland, Kjell O Fossan, Karl J Tronstad, Anne C Johannessen, Olav K Vintermyr, Bj？rn T Gjertsen

Insulin-like growth factor binding protein-3 has dual effects on gastrointestinal stromal tumor cell viability and sensitivity to the anti-tumor effects of imatinib mesylate in vitro

Jheri J Dupart, Jonathan C Trent, Ho-Young Lee, Kenneth R Hess, Andrew K Godwin, Takahiro Taguchi, Wei Zhang

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors

Corina Kohler, Ramin Radpour, Zeinab Barekati, Reza Asadollahi, Johannes Bitzer, Edward Wight, Nicole Bürki, Claude Diesch, Wolfgang Holzgreve, Xiao Zhong

LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells

HaiDan Liu, Hui Zheng, Zhi Duan, DuoSha Hu, Ming Li, SuFang Liu, ZiJian Li, XiYun Deng, ZhenLian Wang, Min Tang, Ying Shi, Wei Yi, Ya Cao

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

Haluk Yuzugullu, Khemais Benhaj, Nuri Ozturk, Serif Senturk, Emine Celik, Asli Toylu, Nilgun Tasdemir, Mustafa Yilmaz, Esra Erdal, Kamil Akcali, Nese Atabey, Mehmet Ozturk

Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models

Ratna Kumari, Aanchal Sharma, Amrendra Ajay, Manoj Bhat

Identification of glucocorticoid-induced leucine zipper as a key regulator of tumor cell proliferation in epithelial ovarian cancer

Nassima Redjimi, Fran？oise Gaudin, Cyril Touboul, Dominique Emilie, Marc Pallardy, Armelle Biola-Vidamment, Hervé Fernandez, Sophie Prévot, Karl Balabanian, Véronique Machelon

STAT5 regulation of BCL10 parallels constitutive NFκB activation in lymphoid tumor cells

Zsuzsanna S Nagy, Matthew J LeBaron, Jeremy A Ross, Abhisek Mitra, Hallgeir Rui, Robert A Kirken

CXCR4 expression heterogeneity in neuroblastoma cells due to ligand-independent regulation

Alex J Carlisle, Christopher A Lyttle, Rosalind Y Carlisle, John M Maris

Regulation of Akt(ser473) phosphorylation by Choline kinase in breast carcinoma cells

Boon Chua, David Gallego-Ortega, Ana de Molina, Axel Ullrich, Juan Lacal, Julian Downward

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals

Ramzi M Mohammad, Jack Wu, Asfar S Azmi, Amro Aboukameel, Angela Sosin, Sherwin Wu, Dajun Yang, Shaomeng Wang, Ayad M Al-Katib

GLI1 genotypes do not predict basal cell carcinoma risk: a case control study

Andrea Watson, Paul Kent, Murad Alam, Amy S Paller, David M Umbach, Joon Yoon, Philip M Iannaccone, David O Walterhouse

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Ymera Pignochino, Giovanni Grignani, Giuliana Cavalloni, Manuela Motta, Marta Tapparo, Stefania Bruno, Alessia Bottos, Loretta Gammaitoni, Giorgia Migliardi, Giovanni Camussi, Marco Alberghini, Bruno Torchio, Stefano Ferrari, Federico Bussolino, Franca Fagioli, Piero Picci, Massimo Aglietta

Identification of small molecule compounds that inhibit the HIF-1 signaling pathway

Menghang Xia, Kun Bi, Ruili Huang, Ming-Hsuang Cho, Srilatha Sakamuru, Susanne C Miller, Hua Li, Yi Sun, John Printen, Christopher P Austin, James Inglese

Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo

Philipp Nuhn, Beat M Künzli, René Hennig, Tomas Mitkus, Tadas Ramanauskas, Rainer Nobiling, Stefan C Meuer, Helmut Friess, Pascal O Berberat

The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias

Luke B Hesson, Thomas L Dunwell, Wendy N Cooper, Daniel Catchpoole, Anna T Brini, Raffaella Chiaramonte, Mike Griffiths, Andrew D Chalmers, Eamonn R Maher, Farida Latif

Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)

Carmen Aceves, Pablo García-Solís, Omar Arroyo-Helguera, Laura Vega-Riveroll, Guadalupe Delgado, Brenda Anguiano

Identification of novel Notch target genes in T cell leukaemia

Nicholas Chadwick, Leo Zeef, Virginia Portillo, Carl Fennessy, Fiona Warrander, Sarah Hoyle, Anne-Marie Buckle

The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth

Valérian Dormoy, Sabrina Danilin, Véronique Lindner, Lionel Thomas, Sylvie Rothhut, Catherine Coquard, Jean-Jacques Helwig, Didier Jacqmin, Hervé Lang, Thierry Massfelder

Lack of functional and expression homology between human and mouse aldo-keto reductase 1C enzymes: implications for modelling human cancers

Pedro Veli？a, Nicholas J Davies, Pedro P Rocha, Heinrich Schrewe, Jonathan P Ride, Chris M Bunce

Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response

Ramaswamy Bhuvaneswari, Yik Gan, Khee Soo, Malini Olivo

Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia

Sonja R？hrs, Wilhelm G Dirks, Claus Meyer, Rolf Marschalek, Michaela Scherr, Robert Slany, Andrew Wallace, Hans G Drexler, Hilmar Quentmeier

HIPK2 modulates p53 activity towards pro-apoptotic transcription

Rosa Puca, Lavinia Nardinocchi, Ada Sacchi, Gideon Rechavi, David Givol, Gabriella D'Orazi

Oncolytic vaccinia therapy of squamous cell carcinoma

Zhenkun Yu, Sen Li, Peter Brader, Nanhai Chen, Yong A Yu, Qian Zhang, Aladar A Szalay, Yuman Fong, Richard J Wong

Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs

Rajendra K Singh, Bal L Lokeshwar

Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells

Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai, Youji Miyamoto

Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility

Luisa Pecorari, Oriano Marin, Chiara Silvestri, Olivia Candini, Elena Rossi, Clara Guerzoni, Sara Cattelani, Samanta A Mariani, Francesca Corradini, Giovanna Ferrari-Amorotti, Laura Cortesi, Rita Bussolari, Giuseppe Raschellà, Massimo R Federico, Bruno Calabretta

Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo

Stephan Emmrich, Weiwei Wang, Katja John, Wenzhong Li, Brigitte M Pützer

Genomic imbalances in precancerous tissues signal oral cancer risk

Cathie Garnis, Raj Chari, Timon PH Buys, Lewei Zhang, Raymond T Ng, Miriam P Rosin, Wan L Lam

PIK3CA alterations in Middle Eastern ovarian cancers

Jehad Abubaker, Prashant Bavi, Wael Al-Haqawi, Zeenath Jehan, Adnan Munkarah, Shahab Uddin, Khawla S Al-Kuraya

A class of DNA-binding peptides from wheat bud causes growth inhibition, G2 cell cycle arrest and apoptosis induction in HeLa cells

Loretta Mancinelli, Paula M De Angelis, Lucia Annulli, Valentina Padovini, Kjell Elgjo, Gian Gianfranceschi

Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients

Hidetaka Yamada, Kazuya Shinmura, Masanori Goto, Moriya Iwaizumi, Hiroyuki Konno, Hideki Kataoka, Masami Yamada, Takachika Ozawa, Toshihiro Tsuneyoshi, Fumihiko Tanioka, Haruhiko Sugimura

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy

Khong Kang, Congju Zhu, Sook Yong, Qiuhan Gao, Meng Wong

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinoma

Qingshan Chang, Jianguo Chen, Kevin J Beezhold, Vince Castranova, Xianglin Shi, Fei Chen

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