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PLOS Genetics

ISSN Print: 1553-7390

ISSN Online:

主页: http://www.plosgenetics.org/article/browse/volume

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Genome-Wide Association Analysis of Incident Coronary Heart Disease (CHD) in African Americans: A Short Report

Maja Barbalic,Alex P. Reiner,Chunyuan Wu,James E. Hixson,Nora Franceschini,Charles B. Eaton,Gerardo Heiss,David Couper,Thomas Mosley,Eric Boerwinkle

A Genetic and Structural Study of Genome Rearrangements Mediated by High Copy Repeat Ty1 Elements

Jason E. Chan,Richard D. Kolodner

A Bow-Tie Genetic Architecture for Morphogenesis Suggested by a Genome-Wide RNAi Screen in Caenorhabditis elegans

Matthew D. Nelson,Elinor Zhou,Karin Kiontke,Hélène Fradin,Grayson Maldonado,Daniel Martin,Khushbu Shah,David H. A. Fitch

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

Elizabeth K. Speliotes equal contributor ,Laura M. Yerges-Armstrong equal contributor,Jun Wu equal contributor,Ruben Hernaez equal contributor,Lauren J. Kim equal contributor,Cameron D. Palmer,Vilmundur Gudnason,Gudny Eiriksdottir,Melissa E. Garcia,Lenore J. Launer,Michael A. Nalls,Jeanne M. Clark,Braxton D. Mitchell,Alan R. Shuldiner,Johannah L. Butler,Marta Tomas,Udo Hoffmann,Shih-Jen Hwang,Joseph M. Massaro,Christopher J. O'Donnell,Dushyant V. Sahani,Veikko Salomaa,Eric E. Schadt,Stephen M. Schwartz,David S. Siscovick,NASH CRN ？,GIANT Consortium ？,MAGIC Investigators ？,Benjamin F. Voight,J. Jeffrey Carr,Mary F. Feitosa,Tamara B. Harris,Caroline S. Fox,Albert V. Smith equal contributor,W. H. Linda Kao equal contributor,Joel N. Hirschhorn equal contributor,Ingrid B. Borecki equal contributor ,GOLD Consortium ？

A Mutation in the Gene Encoding Mitochondrial Mg2+ Channel MRS2 Results in Demyelination in the Rat

Takashi Kuramoto ,Mitsuru Kuwamura,Satoko Tokuda,Takeshi Izawa,Yoshifumi Nakane,Kazuhiro Kitada,Masaharu Akao,Jean-Louis Guénet,Tadao Serikawa

The Toll-Like Receptor Gene Family Is Integrated into Human DNA Damage and p53 Networks

Daniel Menendez equal contributor,Maria Shatz equal contributor,Kathleen Azzam,Stavros Garantziotis,Michael B. Fessler,Michael A. Resnick

Parallel Evolution of a Type IV Secretion System in Radiating Lineages of the Host-Restricted Bacterial Pathogen Bartonella

Philipp Engel,Walter Salzburger,Marius Liesch,Chao-Chin Chang,Soichi Maruyama,Christa Lanz,Alexandra Calteau,Aurélie Lajus,Claudine Médigue,Stephan C. Schuster,Christoph Dehio

Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-Independent Mechanism

Esmeralda Parra-Peralbo,Joaquim Culi

Epistatic Interaction Maps Relative to Multiple Metabolic Phenotypes

Evan S. Snitkin,Daniel Segrè

A Cholinergic-Regulated Circuit Coordinates the Maintenance and Bi-Stable States of a Sensory-Motor Behavior during Caenorhabditis elegans Male Copulation

Yishi Liu,Brigitte LeBeouf,Xiaoyan Guo,Paola A. Correa,Daisy G. Gualberto,Robyn Lints,L. Rene Garcia

The SUVR4 Histone Lysine Methyltransferase Binds Ubiquitin and Converts H3K9me1 to H3K9me3 on Transposon Chromatin in Arabidopsis

Silje V. Veiseth,Mohummad A. Rahman,Kyoko L. Yap,Andreas Fischer,Wolfgang Egge-Jacobsen,Gunter Reuter,Ming-Ming Zhou,Reidunn B. Aalen,Tage Thorstensen

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Adriana Rodríguez-Marí,Catherine Wilson,Tom A. Titus,Cristian Ca？estro,Ruth A. BreMiller,Yi-Lin Yan,Indrajit Nanda,Adam Johnston,John P. Kanki,Erin M. Gray,Xinjun He,Jan Spitsbergen,Detlev Schindler,John H. Postlethwait

Nuclear cGMP-Dependent Kinase Regulates Gene Expression via Activity-Dependent Recruitment of a Conserved Histone Deacetylase Complex

Yan Hao,Ningyi Xu,Andrew C. Box,Laura Schaefer,Kasthuri Kannan,Ying Zhang,Laurence Florens,Christopher Seidel,Michael P. Washburn,Winfried Wiegraebe,Ho Yi Mak

Multiple Loci Are Associated with White Blood Cell Phenotypes

Michael A. Nalls equal contributor ,David J. Couper equal contributor,Toshiko Tanaka equal contributor,Frank J. A. van Rooij equal contributor,Ming-Huei Chen equal contributor,Albert V. Smith equal contributor,Daniela Toniolo equal contributor,Neil A. Zakai equal contributor,Qiong Yang,Andreas Greinacher,Andrew R. Wood,Melissa Garcia,Paolo Gasparini,Yongmei Liu,Thomas Lumley,Aaron R. Folsom,Alex P. Reiner,Christian Gieger,Vasiliki Lagou,Janine F. Felix,Henry V？lzke,Natalia A. Gouskova,Alessandro Biffi,Angela D？ring,Uwe V？lker,Sean Chong,Kerri L. Wiggins,Augusto Rendon,Abbas Dehghan,Matt Moore,Kent Taylor,James G. Wilson,Guillaume Lettre,Albert Hofman,Joshua C. Bis,Nicola Pirastu,Caroline S. Fox,Christa Meisinger,Jennifer Sambrook,Sampath Arepalli,Matthias Nauck,Holger Prokisch,Jonathan Stephens,Nicole L. Glazer,L. Adrienne Cupples,Yukinori Okada,Atsushi Takahashi,Yoichiro Kamatani,Koichi Matsuda,Tatsuhiko Tsunoda,Toshihiro Tanaka,Michiaki Kubo,Yusuke Nakamura,Kazuhiko Yamamoto,Naoyuki Kamatani,Michael Stumvoll,Anke T？njes,Inga Prokopenko,Thomas Illig,Kushang V. Patel,Stephen F. Garner,Brigitte Kuhnel,Massimo Mangino,Ben A. Oostra,Swee Lay Thein,Josef Coresh,H.-Erich Wichmann,Stephan Menzel,JingPing Lin,Giorgio Pistis,André G. Uitterlinden,Tim D. Spector,Alexander Teumer,Gudny Eiriksdottir,Vilmundur Gudnason,Stefania Bandinelli,Timothy M. Frayling,Aravinda Chakravarti,Cornelia M. van Duijn,David Melzer,Willem H. Ouwehand,Daniel Levy,Eric Boerwinkle,Andrew B. Singleton

Assembly of Drosophila Centromeric Chromatin Proteins during Mitosis

Barbara G. Mellone ,Kathryn J. Grive equal contributor,Vladimir Shteyn equal contributor,Sarion R. Bowers,Isaac Oderberg,Gary H. Karpen

A Large Gene Network in Immature Erythroid Cells Is Controlled by the Myeloid and B Cell Transcriptional Regulator PU.1

Sandeep N. Wontakal equal contributor,Xingyi Guo equal contributor,Britta Will,Minyi Shi,Debasish Raha,Milind C. Mahajan,Sherman Weissman,Michael Snyder,Ulrich Steidl,Deyou Zheng ,Arthur I. Skoultchi

A Large-Scale Complex Haploinsufficiency-Based Genetic Interaction Screen in Candida albicans: Analysis of the RAM Network during Morphogenesis

Nike Bharucha equal contributor,Yeissa Chabrier-Roselló equal contributor,Tao Xu,Cole Johnson,Sarah Sobczynski,Qingxuan Song,Craig J. Dobry,Matthew J. Eckwahl,Christopher P. Anderson,Andrew J. Benjamin,Anuj Kumar ,Damian J. Krysan

Alkylation Base Damage Is Converted into Repairable Double-Strand Breaks and Complex Intermediates in G2 Cells Lacking AP Endonuclease

Wenjian Ma,Jim W. Westmoreland,Dmitry A. Gordenin,Mike A. Resnick

Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer

Samah El Ghamrasni equal contributor,Ashwin Pamidi equal contributor,Marie Jo Halaby,Miyuki Bohgaki,Renato Cardoso,Li Li,Shriram Venkatesan,Swaminathan Sethu,Atsushi Hirao,Tak W. Mak,Manoor Prakash Hande,Anne Hakem ,Razqallah Hakem

Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex

Tomoko M. Tabuchi equal contributor,Bart Deplancke equal contributor,Naoki Osato,Lihua J. Zhu,M. Inmaculada Barrasa,Melissa M. Harrison,H. Robert Horvitz,Albertha J. M. Walhout ,Kirsten A. Hagstrom

Mutations in or near the Transmembrane Domain Alter PMEL Amyloid Formation from Functional to Pathogenic

Brenda Watt,Danièle Tenza,Mark A. Lemmon,Susanne Kerje,Gra？a Raposo,Leif Andersson,Michael S. Marks

Temporal Dynamics of Host Molecular Responses Differentiate Symptomatic and Asymptomatic Influenza A Infection

Yongsheng Huang,Aimee K. Zaas,Arvind Rao,Nicolas Dobigeon,Peter J. Woolf,Timothy Veldman,N. Christine ？ien,Micah T. McClain,Jay B. Varkey,Bradley Nicholson,Lawrence Carin,Stephen Kingsmore,Christopher W. Woods,Geoffrey S. Ginsburg ,Alfred O. Hero III

Global Chromosomal Structural Instability in a Subpopulation of Starving Escherichia coli Cells

Dongxu Lin,Ian B. Gibson,Jessica M. Moore,P. C. Thornton,Suzanne M. Leal,P. J. Hastings

Multiple Means to the Same End: The Genetic Basis of Acquired Stress Resistance in Yeast

David B. Berry,Qiaoning Guan,James Hose,Suraiya Haroon,Marinella Gebbia,Lawrence E. Heisler,Corey Nislow,Guri Giaever,Audrey P. Gasch

Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenotypes

Santhosh Girirajan,Zoran Brkanac,Bradley P. Coe,Carl Baker,Laura Vives,Tiffany H. Vu,Neil Shafer,Raphael Bernier,Giovanni B. Ferrero,Margherita Silengo,Stephen T. Warren,Carlos S. Moreno,Marco Fichera,Corrado Romano,Wendy H. Raskind,Evan E. Eichler

Replication and Explorations of High-Order Epistasis Using a Large Advanced Intercross Line Pedigree

Mats Pettersson equal contributor,Francois Besnier equal contributor,Paul B. Siegel,？rjan Carlborg

DAF-12 Regulates a Connected Network of Genes to Ensure Robust Developmental Decisions

Daniel Hochbaum equal contributor,Yue Zhang equal contributor,Carsten Stuckenholz,Paul Labhart,Vassili Alexiadis,René Martin,Hans-Joachim Kn？lker,Alfred L. Fisher

Histone Crosstalk Directed by H2B Ubiquitination Is Required for Chromatin Boundary Integrity

Meiji Kit-Wan Ma,Carol Heath,Alan Hair,Adam G. West

Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

Ashish Lal equal contributor ,Marshall P. Thomas equal contributor,Gabriel Altschuler equal contributor,Francisco Navarro equal contributor,Elizabeth O'Day,Xiao Ling Li,Carla Concepcion,Yoon-Chi Han,Jerome Thiery,Danielle K. Rajani,Aaron Deutsch,Oliver Hofmann,Andrea Ventura,Winston Hide,Judy Lieberman

Caenorhabditis elegans Cyclin D/CDK4 and Cyclin E/CDK2 Induce Distinct Cell Cycle Re-Entry Programs in Differentiated Muscle Cells

Jerome Korzelius,Inge The,Suzan Ruijtenberg,Martine B. W. Prinsen,Vincent Portegijs,Teije C. Middelkoop,Marian J. Groot Koerkamp,Frank C. P. Holstege,Mike Boxem,Sander van den Heuvel

Serratia symbiotica from the Aphid Cinara cedri: A Missing Link from Facultative to Obligate Insect Endosymbiont

Araceli Lamelas,María José Gosalbes,Alejandro Manzano-Marín,Juli Peretó,Andrés Moya,Amparo Latorre

The Bicoid Stability Factor Controls Polyadenylation and Expression of Specific Mitochondrial mRNAs in Drosophila melanogaster

Ana Bratic equal contributor,Anna Wredenberg equal contributor,Sebastian Gr？nke,James B. Stewart,Arnaud Mourier,Benedetta Ruzzenente,Christian Kukat,Rolf Wibom,Bianca Habermann,Linda Partridge,Nils-G？ran Larsson

A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains

Christy L. Avery ,Qianchuan He,Kari E. North,Jose L. Ambite,Eric Boerwinkle,Myriam Fornage,Lucia A. Hindorff,Charles Kooperberg,James B. Meigs,James S. Pankow,Sarah A. Pendergrass,Bruce M. Psaty,Marylyn D. Ritchie,Jerome I. Rotter,Kent D. Taylor,Lynne R. Wilkens,Gerardo Heiss,Dan Yu Lin

Macroautophagy Is Regulated by the UPR–Mediator CHOP and Accentuates the Phenotype of SBMA Mice

Zhigang Yu equal contributor,Adrienne M. Wang equal contributor,Hiroaki Adachi,Masahisa Katsuno,Gen Sobue,Zhenyu Yue,Diane M. Robins,Andrew P. Lieberman

Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease

The IBC 50K CAD Consortium

Genetic Variants at Chromosomes 2q35, 5p12, 6q25.1, 10q26.13, and 16q12.1 Influence the Risk of Breast Cancer in Men

Nick Orr equal contributor ,Rosie Cooke equal contributor,Michael Jones,Olivia Fletcher,Frank Dudbridge,Sarah Chilcott-Burns,Katarzyna Tomczyk,Peter Broderick,Richard Houlston,Alan Ashworth,Anthony Swerdlow

Inference of Relationships in Population Data Using Identity-by-Descent and Identity-by-State

Eric L. Stevens equal contributor,Greg Heckenberg equal contributor,Elisha D. O. Roberson equal contributor,Joseph D. Baugher,Thomas J. Downey,Jonathan Pevsner

Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness

Michael Z. Ludwig equal contributor ,Manu equal contributor,Ralf Kittler,Kevin P. White,Martin Kreitman

Regulation of Caenorhabditis elegans p53/CEP-1–Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

Rachael Rutkowski,Robin Dickinson,Graeme Stewart,Ashley Craig,Marianne Schimpl,Stephen M. Keyse,Anton Gartner

Evidence for Hitchhiking of Deleterious Mutations within the Human Genome

Sung Chun,Justin C. Fay

Specification of Drosophila Corpora Cardiaca Neuroendocrine Cells from Mesoderm Is Regulated by Notch Signaling

Sangbin Park,Erika L. Bustamante,Julie Antonova,Graeme W. McLean,Seung K. Kim

Bacterial Communities of Diverse Drosophila Species: Ecological Context of a Host–Microbe Model System

James Angus Chandler equal contributor ,Jenna Morgan Lang equal contributor,Srijak Bhatnagar,Jonathan A. Eisen,Artyom Kopp

Essential Roles of BCCIP in Mouse Embryonic Development and Structural Stability of Chromosomes

Huimei Lu,Yi-Yuan Huang,Sonam Mehrotra,Roberto Droz-Rosario,Jingmei Liu,Mantu Bhaumik,Eileen White,Zhiyuan Shen

The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus, and PTH

Jingning Liu equal contributor,Fangqiao Lv equal contributor,Wen Sun equal contributor,Chunxiang Tao,Guoxian Ding,Andrew Karaplis,Edward Brown,David Goltzman,Dengshun Miao

MicroRNA Expression and Regulation in Human, Chimpanzee, and Macaque Brains

Hai Yang Hu equal contributor,Song Guo equal contributor,Jiang Xi,Zheng Yan,Ning Fu,Xiaoyu Zhang,Corinna Menzel,Hongyu Liang,Hongyi Yang,Min Zhao,Rong Zeng ,Wei Chen,Svante P？？bo,Philipp Khaitovich

Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transition

Melissa M. Harrison equal contributor,Xiao-Yong Li equal contributor,Tommy Kaplan equal contributor,Michael R. Botchan,Michael B. Eisen

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