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PLOS Genetics

ISSN Print: 1553-7390

ISSN Online:

主页: http://www.plosgenetics.org/article/browse/volume

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RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin

Marisa W. Medina ,Elizabeth Theusch,Devesh Naidoo,Frederick Bauzon,Kristen Stevens,Lara M. Mangravite,Yu-Lin Kuang,Ronald M. Krauss

Trps1 and Its Target Gene Sox9 Regulate Epithelial Proliferation in the Developing Hair Follicle and Are Associated with Hypertrichosis

Katherine A. Fantauzzo,Mazen Kurban,Brynn Levy,Angela M. Christiano

Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling

Jianing Xu,Michael J. McEachern

Antagonistic Gene Activities Determine the Formation of Pattern Elements along the Mediolateral Axis of the Arabidopsis Fruit

Santiago González-Reig,Juan José Ripoll,Antonio Vera,Martin F. Yanofsky,Antonio Martínez-Laborda

Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes

Daniel Wuttke,Richard Connor,Chintan Vora,Thomas Craig,Yang Li,Shona Wood,Olga Vasieva,Robert Shmookler Reis,Fusheng Tang ,Jo？o Pedro de Magalh？es

Comparative Analysis of the Genomes of Two Field Isolates of the Rice Blast Fungus Magnaporthe oryzae

Minfeng Xue equal contributor,Jun Yang equal contributor,Zhigang Li,Songnian Hu,Nan Yao,Ralph A. Dean,Wensheng Zhao,Mi Shen,Haiwang Zhang,Chao Li,Liyuan Liu,Lei Cao,Xiaowen Xu,Yunfei Xing,Tom Hsiang,Ziding Zhang,Jin-Rong Xu ,You-Liang Peng

Reprogramming of H3K27me3 Is Critical for Acquisition of Pluripotency from Cultured Arabidopsis Tissues

Chongsheng He,Xiaofan Chen,Hai Huang,Lin Xu

Retrovolution: HIV–Driven Evolution of Cellular Genes and Improvement of Anticancer Drug Activation

Paola Rossolillo,Flore Winter,Etienne Simon-Loriere,Sarah Gallois-Montbrun,Matteo Negroni

Vsx2 Controls Eye Organogenesis and Retinal Progenitor Identity Via Homeodomain and Non-Homeodomain Residues Required for High Affinity DNA Binding

Changjiang Zou,Edward M. Levine

A Response Regulator Interfaces between the Frz Chemosensory System and the MglA/MglB GTPase/GAP Module to Regulate Polarity in Myxococcus xanthus

Daniela Keilberg,Kristin Wuichet,Florian Drescher,Lotte S？gaard-Andersen

UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex

Yelena Y. Bernadskaya,Andre Wallace,Jillian Nguyen,William A. Mohler,Martha C. Soto

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

Courtney A. Lovejoy,Wendi Li,Steven Reisenweber,Supawat Thongthip,Joanne Bruno,Titia de Lange ,Saurav De,John H. J. Petrini,Patricia A. Sung,Maria Jasin,Joseph Rosenbluh,Yaara Zwang,Barbara A. Weir,Charlie Hatton,Elena Ivanova,Laura Macconaill,Megan Hanna,William C. Hahn,Neal F. Lue,Roger R. Reddel,Yuchen Jiao,Kenneth Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Alan K. Meeker,for the ALT Starr Cancer Consortium

Multiple Roles and Interactions of Tbx4 and Tbx5 in Development of the Respiratory System

Ripla Arora,Ross J. Metzger,Virginia E. Papaioannou

The MicroRNA mir-71 Inhibits Calcium Signaling by Targeting the TIR-1/Sarm1 Adaptor Protein to Control Stochastic L/R Neuronal Asymmetry in C. elegans

Yi-Wen Hsieh,Chieh Chang equal contributor ,Chiou-Fen Chuang equal contributor

Characterization of Inducible Models of Tay-Sachs and Related Disease

Timothy J. Sargeant ,Deborah J. Drage,Susan Wang,Apostolos A. Apostolakis,Timothy M. Cox equal contributor,M. Bego？a Cachón-González equal contributor

Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting

Suneng Fu,Jason Fan,Joshua Blanco,Alfredo Gimenez-Cassina,Nika N. Danial,Steve M. Watkins,G？khan S. Hotamisligil

The Chicken Frizzle Feather Is Due to an α-Keratin (KRT75) Mutation That Causes a Defective Rachis

Chen Siang Ng equal contributor,Ping Wu equal contributor,John Foley,Anne Foley,Merry-Lynn McDonald,Wen-Tau Juan,Chih-Jen Huang,Yu-Ting Lai,Wen-Sui Lo,Chih-Feng Chen,Suzanne M. Leal,Huanmin Zhang,Randall B. Widelitz,Pragna I. Patel,Wen-Hsiung Li ,Cheng-Ming Chuong

Differential Impact of the HEN1 Homolog HENN-1 on 21U and 26G RNAs in the Germline of Caenorhabditis elegans

Leonie M. Kamminga equal contributor,Josien C. van Wolfswinkel equal contributor,Maartje J. Luteijn equal contributor,Lucas J. T. Kaaij,Marloes P. Bagijn,Alexandra Sapetschnig,Eric A. Miska,Eugene Berezikov,René F. Ketting

Human Developmental Enhancers Conserved between Deuterostomes and Protostomes

Shoa L. Clarke,Julia E. VanderMeer,Aaron M. Wenger,Bruce T. Schaar,Nadav Ahituv,Gill Bejerano

Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals

Seung-Hyun Hong equal contributor,Kyu-Sun Lee equal contributor,Su-Jin Kwak,Ae-Kyeong Kim,Hua Bai,Min-Su Jung,O-Yu Kwon,Woo-Joo Song,Marc Tatar,Kweon Yu

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

J. H. Duncan Bassett equal contributor,Apostolos Gogakos,Jacqueline K. White,Holly Evans,Richard M. Jacques,Anne H. van der Spek,Sanger Mouse Genetics Project,Ramiro Ramirez-Solis,Edward Ryder,David Sunter,Alan Boyde,Michael J. Campbell,Peter I. Croucher equal contributor ,Graham R. Williams equal contributor

SEMA3A, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome

Naresh Kumar Hanchate equal contributor,Paolo Giacobini equal contributor,Pierre Lhuillier equal contributor,Jyoti Parkash,Cécile Espy,Corinne Fouveaut,Chrystel Leroy,Stéphanie Baron,Céline Campagne,Charlotte Vanacker,Francis Collier,Corinne Cruaud,Vincent Meyer,Alfons García-Pi？ero,Didier Dewailly,Christine Cortet-Rudelli,Ksenija Gersak,Chantal Metz,Gérard Chabrier,Michel Pugeat,Jacques Young,Jean-Pierre Hardelin ,Vincent Prevot ,Catherine Dodé

Functional Variants in NFKBIE and RTKN2 Involved in Activation of the NF-κB Pathway Are Associated with Rheumatoid Arthritis in Japanese

Keiko Myouzen,Yuta Kochi ,Yukinori Okada,Chikashi Terao,Akari Suzuki,Katsunori Ikari,Tatsuhiko Tsunoda,Atsushi Takahashi,Michiaki Kubo,Atsuo Taniguchi,Fumihiko Matsuda,Koichiro Ohmura,Shigeki Momohara,Tsuneyo Mimori,Hisashi Yamanaka,Naoyuki Kamatani,Ryo Yamada,Yusuke Nakamura,Kazuhiko Yamamoto

New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes

Niina Sandholm equal contributor,Rany M. Salem equal contributor,Amy Jayne McKnight equal contributor,Eoin P. Brennan equal contributor,Carol Forsblom,Tamara Isakova,Gareth J. McKay,Winfred W. Williams,Denise M. Sadlier,Ville-Petteri M？kinen,Elizabeth J. Swan,Cameron Palmer,Andrew P. Boright,Emma Ahlqvist,Harshal A. Deshmukh,Benjamin J. Keller,Huateng Huang,Aila J. Ahola,Emma Fagerholm,Daniel Gordin,Valma Harjutsalo,Bing He,Outi Heikkil？,Kustaa Hietala,Janne Kyt？,P？ivi Lahermo,Markku Lehto,Raija Lithovius,Anne-May ？sterholm,Maija Parkkonen,Janne Pitk？niemi,Milla Roseng？rd-B？rlund,Markku Saraheimo,Cinzia Sarti,Jenny S？derlund,Aino Soro-Paavonen,Anna Syreeni,Lena M. Thorn,Heikki Tikkanen,Nina Tolonen,Karl Tryggvason,Jaakko Tuomilehto,Johan Wadén,Geoffrey V. Gill,Sarah Prior,Candace Guiducci,Daniel B. Mirel,Andrew Taylor,S. Mohsen Hosseini,DCCT/EDIC Research Group,Hans-Henrik Parving,Peter Rossing,Lise Tarnow,Claes Ladenvall,Fran？ois Alhenc-Gelas,Pierre Lefebvre,Vincent Rigalleau,Ronan Roussel,David-Alexandre Tregouet,Anna Maestroni,Silvia Maestroni,Henrik Falhammar,Tianwei Gu,Anna M？llsten,Danut Cimponeriu,Mihai Ioana,Maria Mota,Eugen Mota,Cristian Serafinceanu,Monica Stavarachi,Robert L. Hanson,Robert G. Nelson,Matthias Kretzler,Helen M. Colhoun,Nicolae Mircea Panduru,Harvest F. Gu,Kerstin Brismar,Gianpaolo Zerbini,Samy Hadjadj,Michel Marre,Leif Groop,Maria Lajer,Shelley B. Bull,Daryl Waggott,Andrew D. Paterson,David A. Savage,Stephen C. Bain,Finian Martin,Joel N. Hirschhorn

Functional Evolution of Mammalian Odorant Receptors

Kaylin A. Adipietro,Joel D. Mainland,Hiroaki Matsunami

Evidence of Inbreeding Depression on Human Height

Ruth McQuillan,Niina Eklund,Nicola Pirastu,Maris Kuningas,Brian P. McEvoy,T？nu Esko,Tanguy Corre,Gail Davies,Marika Kaakinen,Leo-Pekka Lyytik？inen,Kati Kristiansson,Aki S. Havulinna,Martin G？gele,Veronique Vitart,Albert Tenesa,Yurii Aulchenko,Caroline Hayward,？sa Johansson,Mladen Boban,Sheila Ulivi,Antonietta Robino,Vesna Boraska,Wilmar Igl,Sarah H. Wild,Lina Zgaga,Najaf Amin,Evropi Theodoratou,Ozren Pola？ek,Giorgia Girotto,Lorna M. Lopez,Cinzia Sala,Jari Lahti,Tiina Laatikainen,Inga Prokopenko,Mart Kals,Jorma Viikari,Jian Yang,Anneli Pouta,Karol Estrada,Albert Hofman,Nelson Freimer,Nicholas G. Martin,Mika K？h？nen,Lili Milani,Markku Heli？vaara,Erkki Vartiainen,Katri R？ikk？nen,Corrado Masciullo,John M. Starr,Andrew A. Hicks,Laura Esposito,Ivana Kol？i？,Susan M. Farrington,Ben Oostra,Tatijana Zemunik,Harry Campbell,Mirna Kirin,Marina Pehlic,Flavio Faletra,David Porteous,Giorgio Pistis,Elisabeth Widén,Veikko Salomaa,Seppo Koskinen,Krista Fischer,Terho Lehtim？ki,Andrew Heath,Mark I. McCarthy,Fernando Rivadeneira,Grant W. Montgomery,Henning Tiemeier,Anna-Liisa Hartikainen,Pamela A. F. Madden,Pio d'Adamo,Nicholas D. Hastie,Ulf Gyllensten,Alan F. Wright,Cornelia M. van Duijn,Malcolm Dunlop,Igor Rudan,Paolo Gasparini,Peter P. Pramstaller,Ian J. Deary,Daniela Toniolo,Johan G. Eriksson,Antti Jula,Olli T. Raitakari,Andres Metspalu,Markus Perola,Marjo-Riitta J？rvelin,André Uitterlinden,Peter M. Visscher,James F. Wilson ,on behalf of the ROHgen Consortium

A Luminal Glycoprotein Drives Dose-Dependent Diameter Expansion of the Drosophila melanogaster Hindgut Tube

Zulfeqhar A. Syed,Anne-Laure Bougé equal contributor,Sunitha Byri equal contributor,Tina M. Chavoshi equal contributor,Erika T？ng,Hervé Bouhin,Iris F. van Dijk-H？rd ,Anne Uv

A Quantitative Comparison of the Similarity between Genes and Geography in Worldwide Human Populations

Chaolong Wang ,Sebastian Z？llner,Noah A. Rosenberg

SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Caenorhabditis elegans Germline

Takamune T. Saito equal contributor,Firaz Mohideen equal contributor,Katherine Meyer,J. Wade Harper,Monica P. Colaiácovo

SCS3 and YFT2 Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR

Robyn D. Moir,David A. Gross,David L. Silver ,Ian M. Willis

Cellular Variability of RpoS Expression Underlies Subpopulation Activation of an Integrative and Conjugative Element

Ryo Miyazaki equal contributor,Marco Minoia equal contributor,Nicolas Pradervand,Sandra Sulser,Friedrich Reinhard,Jan Roelof van der Meer

A General G1/S-Phase Cell-Cycle Control Module in the Flowering Plant Arabidopsis thaliana

Xin'Ai Zhao,Hirofumi Harashima,Nico Dissmeyer,Stefan Pusch,Annika K. Weimer,Jonathan Bramsiepe,Daniel Bouyer,Svenja Rademacher,Moritz K. Nowack,Bela Novak,Stefanie Sprunck,Arp Schnittger

Attenuation of Notch and Hedgehog Signaling Is Required for Fate Specification in the Spinal Cord

Peng Huang ,Fengzhu Xiong,Sean G. Megason,Alexander F. Schier

Genetic Variants on Chromosome 1q41 Influence Ocular Axial Length and High Myopia

Qiao Fan,Veluchamy A. Barathi,Ching-Yu Cheng,Xin Zhou,Akira Meguro,Isao Nakata,Chiea-Chuen Khor,Liang-Kee Goh,Yi-Ju Li,Wan'e Lim,Candice E. H. Ho,Felicia Hawthorne,Yingfeng Zheng,Daniel Chua,Hidetoshi Inoko,Kenji Yamashiro,Kyoko Ohno-Matsui,Keitaro Matsuo,Fumihiko Matsuda,Eranga Vithana,Mark Seielstad,Nobuhisa Mizuki,Roger W. Beuerman,E.-Shyong Tai,Nagahisa Yoshimura,Tin Aung,Terri L. Young,Tien-Yin Wong,Yik-Ying Teo equal contributor ,Seang-Mei Saw equal contributor

Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

Giorgio Giacomo Galli,Kristian Honnens de Lichtenberg,Matteo Carrara,Wolfgang Hans,Manuela Wuelling,Bettina Mentz,Hinke Arnolda Multhaupt,Cathrine Kolster Fog,Klaus Thorleif Jensen,Juri Rappsilber,Andrea Vortkamp,Les Coulton,Helmut Fuchs,Valérie Gailus-Durner,Martin Hrabě de Angelis,Raffaele Adolfo Calogero,John Robert Couchman,Anders Henrik Lund

Bmps and Id2a Act Upstream of Twist1 To Restrict Ectomesenchyme Potential of the Cranial Neural Crest

Ankita Das,J. Gage Crump

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Xuqi Chen,Rebecca McClusky,Jenny Chen,Simon W. Beaven,Peter Tontonoz,Arthur P. Arnold equal contributor,Karen Reue equal contributor

Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma

Janey L. Wiggs equal contributor ,Brian L. Yaspan equal contributor,Michael A. Hauser,Jae H. Kang,R. Rand Allingham,Lana M. Olson,Wael Abdrabou,Bao J. Fan,Dan Y. Wang,Wendy Brodeur,Donald L. Budenz,Joseph Caprioli,Andrew Crenshaw,Kristy Crooks,Elizabeth DelBono,Kimberly F. Doheny,David S. Friedman,Douglas Gaasterland,Terry Gaasterland,Cathy Laurie,Richard K. Lee,Paul R. Lichter,Stephanie Loomis,Yutao Liu,Felipe A. Medeiros,Cathy McCarty,Daniel Mirel,Sayoko E. Moroi,David C. Musch,Anthony Realini,Frank W. Rozsa,Joel S. Schuman,Kathleen Scott,Kuldev Singh,Joshua D. Stein,Edward H. Trager,Paul VanVeldhuisen,Douglas Vollrath,Gadi Wollstein,Sachiko Yoneyama,Kang Zhang,Robert N. Weinreb,Jason Ernst,Manolis Kellis,Tomohiro Masuda,Don Zack,Julia E. Richards,Margaret Pericak-Vance,Louis R. Pasquale ？,Jonathan L. Haines ？

Sequence-Specific Targeting of Dosage Compensation in Drosophila Favors an Active Chromatin Context

Artyom A. Alekseyenko equal contributor,Joshua W. K. Ho equal contributor,Shouyong Peng equal contributor,Marnie Gelbart,Michael Y. Tolstorukov,Annette Plachetka,Peter V. Kharchenko,Youngsook L. Jung,Andrey A. Gorchakov,Erica Larschan,Tingting Gu,Aki Minoda,Nicole C. Riddle,Yuri B. Schwartz,Sarah C. R. Elgin,Gary H. Karpen,Vincenzo Pirrotta,Mitzi I. Kuroda ,Peter J. Park

A Genome-Wide Screen for Genetic Variants That Modify the Recruitment of REST to Its Target Genes

Rory Johnson,Nadine Richter,Gireesh K. Bogu,Akshay Bhinge,Siaw Wei Teng,Siew Hua Choo,Lise O. Andrieux,Cinzia de Benedictis,Ralf Jauch,Lawrence W. Stanton

A Shared Role for RBF1 and dCAP-D3 in the Regulation of Transcription with Consequences for Innate Immunity

Michelle S. Longworth ,James A. Walker,Endre Anderssen,Nam-Sung Moon,Andrew Gladden,Margarete M. S. Heck,Sridhar Ramaswamy,Nicholas J. Dyson

The Functions of Mediator in Candida albicans Support a Role in Shaping Species-Specific Gene Expression

Nathalie Uwamahoro equal contributor,Yue Qu equal contributor,Branka Jelicic,Tricia L. Lo,Cecile Beaurepaire,Farkad Bantun,Tara Quenault,Peter R. Boag,Georg Ramm,Judy Callaghan,Traude H. Beilharz,André Nantel ,Anton Y. Peleg,Ana Traven

MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells

Suling Liu ,Shivani H. Patel,Christophe Ginestier,Ingrid Ibarra,Rachel Martin-Trevino,Shoumin Bai,Sean P. McDermott,Li Shang,Jia Ke,Sing J. Ou,Amber Heath,Kevin J. Zhang,Hasan Korkaya,Shawn G. Clouthier,Emmanuelle Charafe-Jauffret,Daniel Birnbaum,Gregory J. Hannon,Max S. Wicha

Uracil-Containing DNA in Drosophila: Stability, Stage-Specific Accumulation, and Developmental Involvement

Vill？ Muha equal contributor,András Horváth equal contributor,Angéla Békési,Mária Pukáncsik,Barbara Hodoscsek,Gábor Merényi,Gergely Róna,Júlia Batki,István Kiss,Ferenc Jankovics,Péter Vilmos,Miklós Erdélyi,Beáta G. Vértessy

Accurate Prediction of Inducible Transcription Factor Binding Intensities In Vivo

Michael J. Guertin equal contributor,André L. Martins equal contributor,Adam Siepel,John T. Lis

Long-Range Chromosome Organization in E. coli: A Site-Specific System Isolates the Ter Macrodomain

Axel Thiel,Michèle Valens,Isabelle Vallet-Gely,Olivier Espéli,Frédéric Boccard

Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies

Joseph P. Jarvis,Laura B. Scheinfeldt equal contributor,Sameer Soi equal contributor,Charla Lambert equal contributor,Larsson Omberg equal contributor,Bart Ferwerda,Alain Froment,Jean-Marie Bodo,William Beggs,Gabriel Hoffman,Jason Mezey,Sarah A. Tishkoff

Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway

Stephanie M. Correa,Linda L. Washburn,Ravi S. Kahlon,Michelle C. Musson,Gerrit J. Bouma,Eva M. Eicher,Kenneth H. Albrecht

The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum Development

Carine Benadiba,Dario Magnani,Mathieu Niquille,Laurette Morlé,Delphine Valloton,Homaira Nawabi,Aouatef Ait-Lounis,Belkacem Otsmane,Walter Reith,Thomas Theil,Jean-Pierre Hornung,Cécile Lebrand equal contributor ,Bénédicte Durand equal contributor

The Transcription Factor Ultraspiracle Influences Honey Bee Social Behavior and Behavior-Related Gene Expression

Seth A. Ament equal contributor,Ying Wang equal contributor,Chieh-Chun Chen,Charles A. Blatti,Feng Hong,Zhengzheng S. Liang,Nicolas Negre,Kevin P. White,Sandra L. Rodriguez-Zas,Craig A. Mizzen,Saurabh Sinha,Sheng Zhong,Gene E. Robinson

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