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PLOS Genetics

ISSN Print: 1553-7390

ISSN Online:

主页: http://www.plosgenetics.org/article/browse/volume

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The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally

Dan M. Park,Md. Sohail Akhtar,Aseem Z. Ansari,Robert Landick,Patricia J. Kiley

Genome-Wide and Cell-Specific Epigenetic Analysis Challenges the Role of Polycomb in Drosophila Spermatogenesis

Sherif El-Sharnouby,Juliet Redhouse,Robert A. H. White

Evolutionary Tuning of Protein Expression Levels of a Positively Autoregulated Two-Component System

Rong Gao,Ann M. Stock

Specific Tandem Repeats Are Sufficient for Paramutation-Induced Trans-Generational Silencing

Christiane L. Belele equal contributor,Lyudmila Sidorenko equal contributor ,Maike Stam equal contributor,Rechien Bader,Mario A. Arteaga-Vazquez,Vicki L. Chandler

Multiple bHLH Proteins form Heterodimers to Mediate CRY2-Dependent Regulation of Flowering-Time in Arabidopsis

Yawen Liu equal contributor,Xu Li equal contributor,Kunwu Li,Hongtao Liu ,Chentao Lin

Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres

Mauricio Valerio-Santiago,Ana Isabel de los Santos-Velázquez,Fernando Monje-Casas

A Novel Role for Ecdysone in Drosophila Conditioned Behavior: Linking GPCR-Mediated Non-canonical Steroid Action to cAMP Signaling in the Adult Brain

Hiroshi Ishimoto,Zhe Wang,Yi Rao,Chun-Fang Wu,Toshihiro Kitamoto

Reverse PCA, a Systematic Approach for Identifying Genes Important for the Physical Interaction between Protein Pairs

Ifat Lev equal contributor,Marina Volpe equal contributor,Liron Goor,Nelly Levinton,Liach Emuna,Shay Ben-Aroya

Rad52 Sumoylation Prevents the Toxicity of Unproductive Rad51 Filaments Independently of the Anti-Recombinase Srs2

Aline Esta equal contributor,Emilie Ma equal contributor,Pauline Dupaigne,Laurent Maloisel,Rapha？l Guerois,Eric Le Cam,Xavier Veaute,Eric Co？c

Natural Genetic Variation of Integrin Alpha L (Itgal) Modulates Ischemic Brain Injury in Stroke

Sehoon Keum,Han Kyu Lee,Pei-Lun Chu,Matthew J. Kan,Min-Nung Huang,Carol J. Gallione,Michael D. Gunn,Donald C. Lo,Douglas A. Marchuk

Cooperation between RUNX1-ETO9a and Novel Transcriptional Partner KLF6 in Upregulation of Alox5 in Acute Myeloid Leukemia

Russell C. DeKelver,Benjamin Lewin,Kentson Lam,Yukiko Komeno,Ming Yan,Chandler Rundle,Miao-Chia Lo,Dong-Er Zhang

The Human Nuclear Poly(A)-Binding Protein Promotes RNA Hyperadenylation and Decay

Stefan M. Bresson,Nicholas K. Conrad

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

Mariana Igoillo-Esteve ,Anne Genin,Nelle Lambert,Julie Désir,Isabelle Pirson,Baroj Abdulkarim,Nicolas Simonis,Anais Drielsma,Lorella Marselli,Piero Marchetti,Pierre Vanderhaeghen,Décio L. Eizirik,Wim Wuyts,Cécile Julier,Ali J. Chakera,Sian Ellard,Andrew T. Hattersley,Marc Abramowicz ,Miriam Cnop

Nuclear Fragile X Mental Retardation Protein Is localized to Cajal Bodies

Alain Y. Dury equal contributor,Rachid El Fatimy equal contributor,Sandra Tremblay,Timothy M. Rose,Jocelyn C？té,Paul De Koninck,Edouard W. Khandjian

Mobility of the Native Bacillus subtilis Conjugative Plasmid pLS20 Is Regulated by Intercellular Signaling

Praveen K. Singh,Gayetri Ramachandran,Ricardo Ramos-Ruiz,Ramón Peiró-Pastor,David Abia,Ling J. Wu,Wilfried J. J. Meijer

Genome-Wide High-Resolution Mapping of UV-Induced Mitotic Recombination Events in Saccharomyces cerevisiae

Yi Yin,Thomas D. Petes

The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading

Miki Fujioka,Guizhi Sun,James B. Jaynes

Coordination of Cell Proliferation and Cell Fate Determination by CES-1 Snail

Bo Yan,Nadin Memar,Julia Gallinger,Barbara Conradt

PNUTS/PP1 Regulates RNAPII-Mediated Gene Expression and Is Necessary for Developmental Growth

Anita Ciurciu,Louise Duncalf,Vincent Jonchere,Nick Lansdale,Olga Vasieva,Peter Glenday,Andreii Rudenko,Emese Vissi,Neville Cobbe,Luke Alphey,Daimark Bennett

Tracking Proliferative History in Lymphocyte Development with Cre-Mediated Sister Chromatid Recombination

Baojun Zhang,Meifang Dai,Qi-Jing Li ,Yuan Zhuang

Transcription Termination and Chimeric RNA Formation Controlled by Arabidopsis thaliana FPA

Céline Duc,Alexander Sherstnev,Christian Cole,Geoffrey J. Barton ,Gordon G. Simpson

Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway

Catherine E. Smith,Marc L. Mendillo,Nikki Bowen,Hans Hombauer,Christopher S. Campbell,Arshad Desai,Christopher D. Putnam,Richard D. Kolodner

Condensin II Subunit dCAP-D3 Restricts Retrotransposon Mobilization in Drosophila Somatic Cells

Andrew T. Schuster,Kavitha Sarvepalli,Eain A. Murphy,Michelle S. Longworth

Genome Wide Analysis of Narcolepsy in China Implicates Novel Immune Loci and Reveals Changes in Association Prior to Versus After the 2009 H1N1 Influenza Pandemic

Fang Han ,Juliette Faraco,Xiao Song Dong,Hanna M. Ollila,Ling Lin,Jing Li,Pei An,Shan Wang,Ke Wei Jiang,Zhan Cheng Gao,Long Zhao,Han Yan,Ya Nan Liu,Qing Hua Li,Xiao Zhe Zhang,Yan Hu,Jing Yu Wang,Yun Hui Lu,Chang Jun Lu,Wei Zhou,Joachim Hallmayer,Yu Shu Huang,Kingman P. Strohl,Thomas Pollm？cher,Emmanuel Mignot

The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo

Vincenzo Cavalieri ,Raffaella Melfi,Giovanni Spinelli

A Critical Role for PDGFRα Signaling in Medial Nasal Process Development

Fenglei He,Philippe Soriano

Whole Genome Sequencing Identifies a Deletion in Protein Phosphatase 2A That Affects Its Stability and Localization in Chlamydomonas reinhardtii

Huawen Lin,Michelle L. Miller,David M. Granas,Susan K. Dutcher

Dealing with the Evolutionary Downside of CRISPR Immunity: Bacteria and Beneficial Plasmids

Wenyan Jiang,Inbal Maniv,Fawaz Arain,Yaying Wang,Bruce R. Levin,Luciano A. Marraffini

The Prefoldin Complex Regulates Chromatin Dynamics during Transcription Elongation

Gonzalo Millán-Zambrano,Alfonso Rodríguez-Gil,Xenia Pe？ate,Lola de Miguel-Jiménez,Macarena Morillo-Huesca,Nevan Krogan,Sebastián Chávez

Maternal Depletion of Piwi, a Component of the RNAi System, Impacts Heterochromatin Formation in Drosophila

Tingting Gu,Sarah C. R. Elgin

A Shift to Organismal Stress Resistance in Programmed Cell Death Mutants

Meredith E. Judy,Ayumi Nakamura,Anne Huang,Harli Grant,Helen McCurdy,Kurt F. Weiberth,Fuying Gao,Giovanni Coppola,Cynthia Kenyon,Aimee W. Kao

Recent Acquisition of Helicobacter pylori by Baka Pygmies

Sandra Nell equal contributor,Daniel Eibach equal contributor,Valeria Montano,Ayas Maady,Armand Nkwescheu,Jose Siri,Wael F. Elamin,Daniel Falush,Bodo Linz,Mark Achtman ？ ,Yoshan Moodley ？ ,Sebastian Suerbaum ？

Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells

Vera Huang equal contributor,Jiashun Zheng equal contributor,Zhongxia Qi,Ji Wang,Robert F. Place,Jingwei Yu,Hao Li ,Long-Cheng Li

In Vivo Analysis of Lrig Genes Reveals Redundant and Independent Functions in the Inner Ear

Tony del Rio,Allison M. Nishitani,Wei-Ming Yu,Lisa V. Goodrich

Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease

Albino Bacolla,Nuri A. Temiz,Ming Yi,Joseph Ivanic,Regina Z. Cer,Duncan E. Donohue,Edward V. Ball,Uma S. Mudunuri,Guliang Wang,Aklank Jain,Natalia Volfovsky,Brian T. Luke,Robert M. Stephens,David N. Cooper,Jack R. Collins,Karen M. Vasquez

Natural Genetic Transformation Generates a Population of Merodiploids in Streptococcus pneumoniae

Calum Johnston equal contributor,Stéphanie Caymaris equal contributor,Aldert Zomer,Hester J. Bootsma,Marc Prudhomme,Chantal Granadel,Peter W. M. Hermans,Patrice Polard,Bernard Martin,Jean-Pierre Claverys

PKA Controls Calcium Influx into Motor Neurons during a Rhythmic Behavior

Han Wang,Derek Sieburth

The Molecular Chaperone Hsp90 Is Required for Cell Cycle Exit in Drosophila melanogaster

Jennifer L. Bandura,Huaqi Jiang,Derek W. Nickerson,Bruce A. Edgar

Manipulating or Superseding Host Recombination Functions: A Dilemma That Shapes Phage Evolvability

Louis-Marie Bobay ,Marie Touchon,Eduardo P. C. Rocha

Binding of NF-κB to Nucleosomes: Effect of Translational Positioning, Nucleosome Remodeling and Linker Histone H1

Imtiaz Nisar Lone,Manu Shubhdarshan Shukla,John Lalith Charles Richard,Zahary Yordanov Peshev,Stefan Dimitrov ,Dimitar Angelov

Genotype-Environment Interactions Reveal Causal Pathways That Mediate Genetic Effects on Phenotype

Julien Gagneur equal contributor,Oliver Stegle equal contributor,Chenchen Zhu,Petra Jakob,Manu M. Tekkedil,Raeka S. Aiyar,Ann-Kathrin Schuon,Dana Pe'er,Lars M. Steinmetz

Tracking of Chromosome and Replisome Dynamics in Myxococcus xanthus Reveals a Novel Chromosome Arrangement

Andrea Harms equal contributor,Anke Treuner-Lange equal contributor,Dominik Schumacher,Lotte S？gaard-Andersen

System-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity

Megha Rajaram,Jinyu Li,Mikala Egeblad,R. Scott Powers

MicroRNA-17-92, a Direct Ap-2α Transcriptional Target, Modulates T-Box Factor Activity in Orofacial Clefting

Jun Wang,Yan Bai,Hong Li,Stephanie B. Greene,Elzbieta Klysik,Wei Yu,Robert J. Schwartz,Trevor J. Williams,James F. Martin

MEIOB Targets Single-Strand DNA and Is Necessary for Meiotic Recombination

Benoit Souquet equal contributor,Emilie Abby equal contributor,Roxane Hervé,Friederike Finsterbusch,Sophie Tourpin,Ronan Le Bouffant,Clotilde Duquenne,Sébastien Messiaen,Emmanuelle Martini,Jacqueline Bernardino-Sgherri,Attila Toth,René Habert,Gabriel Livera

MYB64 and MYB119 Are Required for Cellularization and Differentiation during Female Gametogenesis in Arabidopsis thaliana

David S. Rabiger,Gary N. Drews

Mitochondrial Transcription Terminator Family Members mTTF and mTerf5 Have Opposing Roles in Coordination of mtDNA Synthesis

Priit J？ers,Samantha C. Lewis,Atsushi Fukuoh,Mikael Parhiala,Simo Ellil？,Ian J. Holt,Howard T. Jacobs

N-acetylglucosamine (GlcNAc) Triggers a Rapid, Temperature-Responsive Morphogenetic Program in Thermally Dimorphic Fungi

Sarah A. Gilmore,Shamoon Naseem,James B. Konopka,Anita Sil

Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

Conall M. O'Seaghdha ？,Hongsheng Wu,Qiong Yang,Karen Kapur,Idris Guessous ？,Annie Mercier Zuber,Anna K？ttgen ？,Candice Stoudmann,Alexander Teumer,Zoltán Kutalik,Massimo Mangino,Abbas Dehghan,Weihua Zhang,Gudny Eiriksdottir,Guo Li,Toshiko Tanaka,Laura Portas,Lorna M. Lopez,Caroline Hayward,Kurt Lohman,Koichi Matsuda,Sandosh Padmanabhan,Dmitri Firsov,Rossella Sorice,Sheila Ulivi,A. Catharina Brockhaus,Marcus E. Kleber,Anubha Mahajan,Florian D. Ernst,Vilmundur Gudnason,Lenore J. Launer,Aurelien Mace,Eric Boerwinckle,Dan E. Arking,Chizu Tanikawa,Yusuke Nakamura,Morris J. Brown,Jean-Michel Gaspoz,Jean-Marc Theler,David S. Siscovick,Bruce M. Psaty,Sven Bergmann,Peter Vollenweider,Veronique Vitart,Alan F. Wright,Tatijana Zemunik,Mladen Boban,Ivana Kolcic,Pau Navarro,Edward M. Brown,Karol Estrada,Jingzhong Ding,Tamara B. Harris,Stefania Bandinelli,Dena Hernandez,Andrew B. Singleton,Giorgia Girotto,Daniela Ruggiero,Adamo Pio d'Adamo,Antonietta Robino,Thomas Meitinger,Christa Meisinger,Gail Davies,John M. Starr,John C. Chambers,Bernhard O. Boehm,Bernhard R. Winkelmann,Jie Huang,Federico Murgia,Sarah H. Wild,Harry Campbell,Andrew P. Morris,Oscar H. Franco,Albert Hofman,Andre G. Uitterlinden,Fernando Rivadeneira,Uwe V？lker,Anke Hannemann,Reiner Biffar,Wolfgang Hoffmann,So–Youn Shin,Pierre Lescuyer,Hughes Henry,Claudia Schurmann,The SUNLIGHT consortium,The GEFOS consortium,Patricia B. Munroe,Paolo Gasparini,Nicola Pirastu,Marina Ciullo,Christian Gieger,Winfried M？rz,Lars Lind

miR-1/133a Clusters Cooperatively Specify the Cardiomyogenic Lineage by Adjustment of Myocardin Levels during Embryonic Heart Development

Katharina Wystub,Johannes Besser,Angela Bachmann,Thomas Boettger ,Thomas Braun

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