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PLOS Genetics

ISSN Print: 1553-7390

ISSN Online:

主页: http://www.plosgenetics.org/article/browse/volume

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Quantitative Genetics Identifies Cryptic Genetic Variation Involved in the Paternal Regulation of Seed Development

Nuno D. Pires？,Marian Bemer？,Lena M. Müller？,Célia Baroux？,Charles Spillane？,Ueli Grossniklaus

Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila

Arunesh Saras？,Mark A. Tanouye

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

Michèle Telorack？,Michael Meyer？,Irina Ingold？,Marcus Conrad？,Wilhelm Bloch？,Sabine Werner

The LSH/DDM1 Homolog MUS-30 Is Required for Genome Stability, but Not for DNA Methylation in Neurospora crassa

Evelina Y. Basenko？,Masayuki Kamei？,Lexiang Ji？,Robert J. Schmitz？,Zachary A. Lewis

Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei

Danae Schulz？,Maryam Zaringhalam？,F. Nina Papavasiliou？,Hee-Sook Kim

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

Elvir Becirovic？,Sybille B？hm？,Ong Nam Phuong Nguyen？,Lisa Maria Riedmayr？,Mirja Annika Koch？,Elisabeth Schulze？,Susanne Kohl？,Oliver Borsch？,Tiago Santos-Ferreira？,Marius Ader

Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation

Maximilian G. Plach？,Bernd Reisinger？,Reinhard Sterner？,Rainer Merkl

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

David Reynolds？,Brigitte T. Hofmeister？,Laura Cliffe？,Magdy Alabady？,T. Nicolai Siegel？,Robert J. Schmitz？,Robert Sabatini

Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila

Hsueh-Yen Ku？,Vamsi K. Gangaraju？,Hongying Qi？,Na Liu？,Haifan Lin

Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7

Farhoud Faraji？,Ying Hu？,Howard H. Yang？,Maxwell P. Lee？,G. Sebastian Winkler？,Markus Hafner？,Kent W. Hunter

Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation

Daniela Eckert？,Nicole Andrée？,Aleh Razanau？,Susanne Zock-Emmenthal？,Martin Lützelberger？,Susann Plath？,Henning Schmidt？,Angel Guerra-Moreno？,Luca Cozzuto？,José Ayté

Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia

J. Pedro Fernández-Murray？,Sergey V. Prykhozhij？,J. Noelia Dufay？,Shelby L. Steele？,Daniel Gaston？,Gheyath K. Nasrallah？,Andrew J. Coombs？,Robert S. Liwski？,Conrad V. Fernandez？,Jason N. Berman

A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development

Jingyue Xu？,Han Liu？,Yu Lan？,Bruce J. Aronow？,Vladimir V. Kalinichenko？,Rulang Jiang

Preferential Allele Expression Analysis Identifies Shared Germline and Somatic Driver Genes in Advanced Ovarian Cancer

Najeeb M. Halabi？,Alejandra Martinez？,Halema Al-Farsi？,Eliane Mery？,Laurence Puydenus？,Pascal Pujol？,Hanif G. Khalak？,Cameron McLurcan？,Gwenael Ferron？,Denis Querleu

Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements

Hua Wang？,Chunmei Liu？,Jingfei Cheng？,Jian Liu？,Lei Zhang？,Chongsheng He？,Wen-Hui Shen？,Hong Jin？,Lin Xu？,Yijing Zhang

MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria

Ilaria Dalla Rosa？,Yolanda Cámara？,Romina Durigon？,Chloe F. Moss？,Sara Vidoni？,Gokhan Akman？,Lilian Hunt？,Mark A. Johnson？,Sarah Grocott？,Liya Wang

A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity

Qingyun Li？,Scott Barish？,Sumie Okuwa？,Abigail Maciejewski？,Alicia T. Brandt？,Dominik Reinhold？,Corbin D. Jones？,Pelin Cayirlioglu Volkan

P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality

Erin A. Ronayne？,Y. C. Serena Wan？,Beth A. Boudreau？,Robert Landick？,Michael M. Cox

PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation

Yan Yang？,Wencheng Li？,Mainul Hoque？,Liming Hou？,Steven Shen？,Bin Tian？,Brian D. Dynlacht

Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks

María Belén Federico？,María Belén Vallerga？,Analía Radl？,Natalia Soledad Paviolo？,José Luis Bocco？,Marina Di Giorgio？,Gastón Soria？,Vanesa Gottifredi

Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation

Gongshi Bai？,Marcus B. Smolka？,John C. Schimenti

SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification

Amel Alqadah？,Yi-Wen Hsieh？,Jennifer A. Schumacher？,Xiaohong Wang？,Sean A. Merrill？,Grethel Millington？,Brittany Bayne？,Erik M. Jorgensen？,Chiou-Fen Chuang

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells

Dakshayani Lomada？,Manju Jain？,Michelle Bolner？,Kaitlin A. G. Reeh？,Rhea Kang？,Madhava C. Reddy？,John DiGiovanni？,Ellen R. Richie

Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells

Rumi Satoh？,Kiyokazu Kakugawa？,Takuwa Yasuda？,Hisahiro Yoshida？,Maria Sibilia？,Yoshimoto Katsura？,Ben Levi？,Jakub Abramson？,Yoko Koseki？,Haruhiko Koseki

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs

Courtney K. Burrows？,Nicholas E. Banovich？,Bryan J. Pavlovic？,Kristen Patterson？,Irene Gallego Romero？,Jonathan K. Pritchard？,Yoav Gilad

Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility

Tuomo Mantere？,Robert Winqvist？,Saila Kauppila？,Mervi Grip？,Arja Jukkola-Vuorinen？,Anna Tervasm？ki？,Katrin Rapakko？,Katri Pylk？s

A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies

Masakazu Kohda？,Yoshimi Tokuzawa？,Yoshihito Kishita？,Hiromi Nyuzuki？,Yohsuke Moriyama？,Yosuke Mizuno？,Tomoko Hirata？,Yukiko Yatsuka？,Yzumi Yamashita-Sugahara？,Yutaka Nakachi

Adaptive Protein Evolution in Animals and the Effective Population Size Hypothesis

Nicolas Galtier

Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools

Omar Soukarieh？,Pascaline Gaildrat？,Mohamad Hamieh？,Aurélie Drouet？,Stéphanie Baert-Desurmont？,Thierry Frébourg？,Mario Tosi？,Alexandra Martins

A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation

Lauren L. Lohmer？,Matthew R. Clay？,Kaleb M. Naegeli？,Qiuyi Chi？,Joshua W. Ziel？,Elliott J. Hagedorn？,Jieun E. Park？,Ranjay Jayadev？,David R. Sherwood

TrpA1 Regulates Defecation of Food-Borne Pathogens under the Control of the Duox Pathway

Eun Jo Du？,Tae Jung Ahn？,Ilmin Kwon？,Ji Hye Lee？,Jeong-Ho Park？,Sun Hwa Park？,Tong Mook Kang？,Hana Cho？,Tae Jin Kim？,Hyung-Wook Kim

Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression

Jie-Li Mao？,Zi-Qing Miao？,Zhen Wang？,Lin-Hui Yu？,Xiao-Teng Cai？,Cheng-Bin Xiang

CFLAP1 and CFLAP2 Are Two bHLH Transcription Factors Participating in Synergistic Regulation of AtCFL1-Mediated Cuticle Development in Arabidopsis

Shibai Li？,Xiaochen Wang？,Shan He？,Jieru Li？,Qingpei Huang？,Takato Imaizumi？,Leqing Qu？,Genji Qin？,Li-Jia Qu？,Hongya Gu

The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts

Simona Cugusi？,Yujing Li？,Peng Jin？,John C. Lucchesi

A Spatial Framework for Understanding Population Structure and Admixture

Gideon S. Bradburd？,Peter L. Ralph？,Graham M. Coop

Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier

Emma Bondy-Chorney？,Tara E. Crawford Parks？,Aymeric Ravel-Chapuis？,Roscoe Klinck？,Lynda Rocheleau？,Martin Pelchat？,Benoit Chabot？,Bernard J. Jasmin？,Jocelyn C？té

Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation

Long Guo？,Hiroshi Yamashita？,Ikuyo Kou？,Aki Takimoto？,Makiko Meguro-Horike？,Shin-ichi Horike？,Tetsushi Sakuma？,Shigenori Miura？,Taiji Adachi？,Takashi Yamamoto

A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction

Mikolaj J. Sulkowski？,Tae Hee Han？,Carolyn Ott？,Qi Wang？,Esther M. Verheyen？,Jennifer Lippincott-Schwartz？,Mihaela Serpe

The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability

Sabine S. Lange？,Junya Tomida？,Karen S. Boulware？,Sarita Bhetawal？,Richard D. Wood

Consent Codes: Upholding Standard Data Use Conditions

Stephanie O. M. Dyke？,Anthony A. Philippakis？,Jordi Rambla De Argila？,Dina N. Paltoo？,Erin S. Luetkemeier？,Bartha M. Knoppers？,Anthony J. Brookes？,J. Dylan Spalding？,Mark Thompson？,Marco Roos

H-NS Facilitates Sequence Diversification of Horizontally Transferred DNAs during Their Integration in Host Chromosomes

Koichi Higashi？,Toru Tobe？,Akinori Kanai？,Ebru Uyar？,Shu Ishikawa？,Yutaka Suzuki？,Naotake Ogasawara？,Ken Kurokawa？,Taku Oshima

Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

Madalena C. Carneiro？,Catarina M. Henriques？,Joana Nabais？,Tania Ferreira？,Tania Carvalho？,Miguel Godinho Ferreira

Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis

Marc Amoyel？,Jason Anderson？,Annabelle Suisse？,Johanna Glasner？,Erika A. Bach

Innovation of a Regulatory Mechanism Modulating Semi-determinate Stem Growth through Artificial Selection in Soybean

Yunfeng Liu？,Dajian Zhang？,Jieqing Ping？,Shuai Li？,Zhixiang Chen？,Jianxin Ma

Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress

Michelle L. Oeser？,Triana Amen？,Cory M. Nadel？,Amanda I. Bradley？,Benjamin J. Reed？,Ramon D. Jones？,Janani Gopalan？,Daniel Kaganovich？,Richard G. Gardner

Specific Hsp100 Chaperones Determine the Fate of the First Enzyme of the Plastidial Isoprenoid Pathway for Either Refolding or Degradation by the Stromal Clp Protease in Arabidopsis

Pablo Pulido？,Ernesto Llamas？,Briardo Llorente？,Salvador Ventura？,Louwrance P. Wright？,Manuel Rodríguez-Concepción

ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

John R. Pearson？,Federico Zurita？,Laura Tomás-Gallardo？,Alfonsa Díaz-Torres？,María del Carmen Díaz de la Loza？,Kristian Franze？,María D. Martín-Bermudo？,Acaimo González-Reyes

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

Yunpeng Wang？,Wesley K. Thompson？,Andrew J. Schork？,Dominic Holland？,Chi-Hua Chen？,Francesco Bettella？,Rahul S. Desikan？,Wen Li？,Aree Witoelar？,Verena Zuber

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis

Julia E. Draper？,Patrycja Sroczynska？,Olga Tsoulaki？,Hui Sun Leong？,Muhammad Z. H. Fadlullah？,Crispin Miller？,Valerie Kouskoff？,Georges Lacaud

Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects

Dorothy Concepcion？,Kevin D. Ross？,Kasey R. Hutt？,Gene W. Yeo？,Bruce A. Hamilton

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