Tough Mining

Steven Dickman

Novel “Checkpoint” Mechanism Mediates DNA Damage Responses

For Insulin Signaling Pathways in Flies, Size Matters

Clocking in Pillow Time without the Pillow

The Left–Right Polarity Puzzle: Determining Embryonic Handedness

William B. Wood

A Recipe for Self-Renewing Brain

Functional Genomic Analysis of C. elegans Molting

Alison R. Frand,Sascha Russel,Gary Ruvkun

The Molting Worm Sheds Its Genetic Secrets

Genomics Helps Explain Why Some Like It Hot

Cancer-Causing Genes Can Convert Even the Most Committed Cells

Improved Statistical Tools Reveal Many Linked Loci

Creating a Window into the Developing Brain: Observing Axon Growth in Live Mice

Field Tested: Grasslands Won’t Help Buffer Climate Change as CO2 Levels Rise

Comment on “Recent Origin and Cultural Reversion of a Hunter–Gatherer Group”

Tony Waters

A Mouse Model for Parkinson Disease

Islands in the Genome Promote Speciation

New Genomic Approach Predicts True Evolutionary History of Bacterial Genomes

Monitoring Malaria: Genomic Activity of the Parasite in Human Blood Cells

Out of the Way

Glenn Otis Brown

Functional Analysis of RSS Spacers

Neuroscience Networks

Thomas R. Insel,Nora D. Volkow,Ting-Kai Li,James F. Battey Jr,Story C. Landis

Microarray Analysis

Greg Gibson

Mathematical Modeling Predicts How Proteins Affect Cellular Communication

Why PLoS Became a Publisher

Patrick O. Brown,Michael B. Eisen,Harold E. Varmus

Developmental Origins and Evolution of Buchnera Host Cells

What Controls Variation in Human Skin Color?

Gregory S. Barsh

Army Ants Trapped by Their Evolutionary History

Frédéric Delsuc

Retraining the Brain to Recover Movement

Gene Chip for Viral Discovery

Cell-by-Cell Dissection of Gene Expression and Chromosomal Interactions Reveals Consequences of Nuclear Reorganization

Brian Harmon,John Sedat

Tubeworm May Live Longer by Cycling Its Sulfur Downward

How the Brain Signals a Sound Source

Two-Way Traffic in B Cell Development: Implications for Immune Tolerance

The Chimp Genome Reveals a Retroviral Invasion in Primate Evolution

Forecasting the Path of a Raccoon Rabies Epidemic

Separating Sisters: Shugoshin Protects SA2 at Centromeres but Not at Chromosome Arms

Gamma-Herpesvirus Latency Requires T Cell Evasion during Episome Maintenance

Neil J. Bennett,Janet S. May,Philip G. Stevenson

Plus ？a Change: Gene Enhancers Upset Evolutionary Assumption

Gray Wolves Help Scavengers Ride Out Climate Change

Chromosome Cohesion: A Cycle of Holding Together and Falling Apart

Jennifer Gerton

The New Yeast Is a Mouse

Rhona H. Borts

When Art, Science, and Culture Commingle

Cheryl A. Kerfeld

Neo-Lymphoid Aggregates in the Adult Liver Can Initiate Potent Cell-Mediated Immunity

Melanie Greter,Janin Hofmann,Burkhard Becher

Liver Is T Cells' Ace in the Hole

Mary Hoff

Engineering Sexless Seeds as a Path to High-Yield Crops

Robin Meadows

Turning Meiosis into Mitosis

Isabelle d'Erfurth,Sylvie Jolivet,Nicole Froger,Olivier Catrice,Maria Novatchkova,Rapha？l Mercier

Change for the Better: Phosphoregulation of Proteins Drives Evolution

William Mair

Light, Sleep, and Circadian Rhythms: Together Again

Derk-Jan Dijk,Simon N. Archer

Serotonin's Role in the Pancreas Revealed at Last

Richard Robinson

Neurons Help Bridge the Brain's Communication Gap

Rachel Jones