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PLOS ONE

ISSN Print: 1932-6203

ISSN Online:

主页: http://www.plosone.org/

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Genetic Variation for Cardiac Dysfunction in Drosophila

Karen A. Ocorr, Timothy Crawley, Greg Gibson, Rolf Bodmer

A Structural Split in the Human Genome

Clara S.M. Tang, Richard J. Epstein

Personal Drug Selection: Problem-Based Learning in Pharmacology: Experience from a Medical School in Nepal

P. Ravi Shankar, Subish Palaian, Sudesh Gyawali, Pranaya Mishra, Lalit Mohan

The Circadian System Is a Target and Modulator of Prenatal Cocaine Effects

Eva H. Shang, Irina V. Zhdanova

Genome-Wide Identification of Alternatively Spliced mRNA Targets of Specific RNA-Binding Proteins

Mark D. Robida, Andrew Rahn, Ravinder Singh

Phylogeny of Diving Beetles Reveals a Coevolutionary Arms Race between the Sexes

Johannes Bergsten, Kelly B. Miller

Molecular Biogeography: Towards an Integrated Framework for Conserving Pan-African Biodiversity

Yoshan Moodley, Michael W. Bruford

LRP1 Functions as an Atheroprotective Integrator of TGFβ and PDGF Signals in the Vascular Wall: Implications for Marfan Syndrome

Philippe Boucher, Wei-Ping Li, Rachel L. Matz, Yoshiharu Takayama, Johan Auwerx, Richard G.W. Anderson, Joachim Herz

Engineering and Characterization of an Enhanced Fluorescent Protein Voltage Sensor

Dimitar Dimitrov, You He, Hiroki Mutoh, Bradley J. Baker, Lawrence Cohen, Walther Akemann, Thomas Kn？pfel

A Novel Unsupervised Method to Identify Genes Important in the Anti-viral Response: Application to Interferon/Ribavirin in Hepatitis C Patients

Leonid I. Brodsky, Abdus S. Wahed, Jia Li, John E. Tavis, Takuma Tsukahara, Milton W. Taylor

Mapping of QTL for Resistance against the Crucifer Specialist Herbivore Pieris brassicae in a New Arabidopsis Inbred Line Population, Da(1)-12×Ei-2

Marina Pfalz, Heiko Vogel, Thomas Mitchell-Olds, Juergen Kroymann

Recruitment of Polo Kinase to the Spindle Midzone during Cytokinesis Requires the Feo/Klp3A Complex

Pier Paolo D'Avino, Vincent Archambault, Marcin R. Przewloka, Wei Zhang, Kathryn S. Lilley, Ernest Laue, David M. Glover

Expression, Processing, and Localization of PmpD of Chlamydia trachomatis Serovar L2 during the Chlamydial Developmental Cycle

Andrey O. Kiselev, Walter E. Stamm, John R. Yates, Mary F. Lampe

IgG Fc Receptors Provide an Alternative Infection Route for Murine Gamma-Herpesvirus-68

Gustavo T. Rosa, Laurent Gillet, Christopher M. Smith, Brigitte D. de Lima, Philip G. Stevenson

Two Chikungunya Isolates from the Outbreak of La Reunion (Indian Ocean) Exhibit Different Patterns of Infection in the Mosquito, Aedes albopictus

Marie Vazeille, Sara Moutailler, Daniel Coudrier, Claudine Rousseaux, Huot Khun, Michel Huerre, Julien Thiria, Jean-Sébastien Dehecq, Didier Fontenille, Isabelle Schuffenecker, Philippe Despres, Anna-Bella Failloux

Induced Prion Protein Controls Immune-Activated Retroviruses in the Mouse Spleen

Marius L？tscher, Mike Recher, Karl S. Lang, Alexander Navarini, Lukas Hunziker, Roger Santimaria, Markus Glatzel, Petra Schwarz, Jürg B？ni, Rolf M. Zinkernagel

Common Human Cancer Genes Discovered by Integrated Gene-Expression Analysis

Yan Lu, Yijun Yi, Pengyuan Liu, Weidong Wen, Michael James, Daolong Wang, Ming You

Accelerated Variant of Idiopathic Pulmonary Fibrosis: Clinical Behavior and Gene Expression Pattern

Moisés Selman, Guillermo Carrillo, Andrea Estrada, Mayra Mejia, Carina Becerril, José Cisneros, Miguel Gaxiola, Rogelio Pérez-Padilla, Carmen Navarro, Thomas Richards, James Dauber, Talmadge E. King, Annie Pardo, Naftali Kaminski

Human ClC-6 Is a Late Endosomal Glycoprotein that Associates with Detergent-Resistant Lipid Domains

Sofie Ignoul, Jeannine Simaels, Diane Hermans, Wim Annaert, Jan Eggermont

Predicting Pneumonia and Influenza Mortality from Morbidity Data

Lise Denoeud, Clément Turbelin, Séverine Ansart, Alain-Jacques Valleron, Antoine Flahault, Fabrice Carrat

Virtual Northern Analysis of the Human Genome

Evan H. Hurowitz, Iddo Drori, Victoria C. Stodden, David L. Donoho, Patrick O. Brown

High-Yield Hydrogen Production from Starch and Water by a Synthetic Enzymatic Pathway

Y.-H. Percival Zhang, Barbara R. Evans, Jonathan R. Mielenz, Robert C. Hopkins, Michael W.W. Adams

Can ID Repetitive Elements Serve as Cis-acting Dendritic Targeting Elements? An In Vivo Study

Tasneem Khanam, Carsten A. Raabe, Martin Kiefmann, Sergej Handel, Boris V. Skryabin, Jürgen Brosius

A Multicassette Gateway Vector Set for High Throughput and Comparative Analyses in Ciona and Vertebrate Embryos

Agnès Roure, Ute Rothb？cher, Fran？ois Robin, Eva Kalmar, Giustina Ferone, Clément Lamy, Caterina Missero, Ferenc Mueller, Patrick Lemaire

Ultrasonic Communication in Rats: Can Playback of 50-kHz Calls Induce Approach Behavior?

Markus W？hr, Rainer K. W. Schwarting

Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants

Anke Hinney, Thuy Trang Nguyen, André Scherag, Susann Friedel, Günter Br？nner, Timo Dirk Müller, Harald Grallert, Thomas Illig, H.-Erich Wichmann, Winfried Rief, Helmut Sch？fer, Johannes Hebebrand

Multi-Locus Sequence Typing of Bartonella henselae Isolates from Three Continents Reveals Hypervirulent and Feline-Associated Clones

Mardjan Arvand, Edward J. Feil, Michael Giladi, Henri-Jean Boulouis, Juliane Viezens

Primate TNF Promoters Reveal Markers of Phylogeny and Evolution of Innate Immunity

Andres Baena, Alan R. Mootnick, James V. Falvo, Alla V. Tsytsykova, Filipa Ligeiro, Ousmane M. Diop, Claudia Brieva, Pascal Gagneux, Stephen J. O'Brien, Oliver A. Ryder, Anne E. Goldfeld

A National Survey of Teachers on Antiretroviral Therapy in Malawi: Access, Retention in Therapy and Survival

Simon D. Makombe, Andreas Jahn, Hannock Tweya, Stuart Chuka, Joseph Kwong-Leung Yu, Mindy Hochgesang, John Aberle-Grasse, Lameck Thambo, Erik J. Schouten, Kelita Kamoto, Anthony D. Harries

The Role of Rab3a in Secretory Vesicle Docking Requires Association/Dissociation of Guanidine Phosphates and Munc18-1

Jan R.T. van Weering, Ruud F. Toonen, Matthijs Verhage

Modeling Insertional Mutagenesis Using Gene Length and Expression in Murine Embryonic Stem Cells

Alex S. Nord, Karen Vranizan, Whittemore Tingley, Alexander C. Zambon, Kristina Hanspers, Loren G. Fong, Yan Hu, Peter Bacchetti, Thomas E. Ferrin, Patricia C. Babbitt, Scott W. Doniger, William C. Skarnes, Stephen G. Young, Bruce R. Conklin

Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation

Sharon J. Sequeira, Aparna C. Ranganathan, Alejandro P. Adam, Bibiana V. Iglesias, Eduardo F. Farias, Julio A. Aguirre-Ghiso

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?

Peter R. Teske, Isabelle Papadopoulos, Christopher D. McQuaid, Brent K. Newman, Nigel P. Barker

High Costs of Female Choice in a Lekking Lizard

Maren N. Vitousek, Mark A. Mitchell, Anthony J. Woakes, Michael D. Niemack, Martin Wikelski

Bone Microenvironment Specific Roles of ITAM Adapter Signaling during Bone Remodeling Induced by Acute Estrogen-Deficiency

Yalei Wu, James Torchia, Wei Yao, Nancy E. Lane, Lewis L. Lanier, Mary C. Nakamura, Mary Beth Humphrey

Lymphocytes and the Dap12 Adaptor Are Key Regulators of Osteoclast Activation Associated with Gonadal Failure

Adrienne Anginot, Romain Dacquin, Marlène Mazzorana, Pierre Jurdic

“Sexual” Population Structure and Genetics of the Malaria Agent P. falciparum

Themba Mzilahowa, Philip J. McCall, Ian M. Hastings

Haemoglobin C and S Role in Acquired Immunity against Plasmodium falciparum Malaria

Federica Verra, Jacques Simpore, George M. Warimwe, Kevin K. Tetteh, Tevis Howard, Faith H. A. Osier, Germana Bancone, Pamela Avellino, Isa Blot, Greg Fegan, Peter C. Bull, Thomas N. Williams, David J. Conway, Kevin Marsh, David Modiano

Ets-1 Confers Cranial Features on Neural Crest Delamination

Eric Théveneau, Jean-Loup Duband, Muriel Altabef

Impaired Inhibitory Control in Recreational Cocaine Users

Lorenza S. Colzato, Wery P. M. van den Wildenberg, Bernhard Hommel

γH2AX Foci Form Preferentially in Euchromatin after Ionising-Radiation

Ian G. Cowell, Nicola J. Sunter, Prim B. Singh, Caroline A. Austin, Barbara W. Durkacz, Michael J. Tilby

Austro-Asiatic Tribes of Northeast India Provide Hitherto Missing Genetic Link between South and Southeast Asia

B. Mohan Reddy, B. T. Langstieh, Vikrant Kumar, T. Nagaraja, A. N. S. Reddy, Aruna Meka, A. G. Reddy, K. Thangaraj, Lalji Singh

Horizontal Gene Transfer Regulation in Bacteria as a “Spandrel” of DNA Repair Mechanisms

Saliou Fall, Anne Mercier, Franck Bertolla, Alexandra Calteau, Laurent Gueguen, Guy Perrière, Timothy M. Vogel, Pascal Simonet

Neutrophil Activation Status in Stable Coronary Artery Disease

Eva S？rndahl, Ida Bergstr？m, Veronika Patcha Brodin, Johnny Nijm, Helen Lundqvist Setterud, Lena Jonasson

Boosting BCG with Recombinant Modified Vaccinia Ankara Expressing Antigen 85A: Different Boosting Intervals and Implications for Efficacy Trials

Ansar A. Pathan, Clare R. Sander, Helen A. Fletcher, Ian Poulton, Nicola C. Alder, Natalie E. R. Beveridge, Kathryn T. Whelan, Adrian V. S. Hill, Helen McShane

Murine Gammaherpesvirus-68 Inhibits Antigen Presentation by Dendritic Cells

Christopher M. Smith, Michael B. Gill, Janet S. May, Philip G. Stevenson

Membrane Recruitment of Scaffold Proteins Drives Specific Signaling

Frédéric Pincet

Population Response to Habitat Fragmentation in a Stream-Dwelling Brook Trout Population

Benjamin H. Letcher, Keith H. Nislow, Jason A. Coombs, Matthew J. O'Donnell, Todd L. Dubreuil

HER2 Status in Ovarian Carcinomas: A Multicenter GINECO Study of 320 Patients

Marianne Tuefferd, Jér？me Couturier, Frédérique Penault-Llorca, Anne Vincent-Salomon, Philippe Bro？t, Jean-Paul Guastalla, Djelila Allouache, Martin Combe, Béatrice Weber, Eric Pujade-Lauraine, Sophie Camilleri-Bro？t

Ankyrin-B Syndrome: Enhanced Cardiac Function Balanced by Risk of Cardiac Death and Premature Senescence

Peter J. Mohler, Jane A. Healy, Hui Xue, Annibale A. Puca, Crystal F. Kline, R. Rand Allingham, Evangelia G. Kranias, Howard A. Rockman, Vann Bennett

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