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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1476-5462

ISSN Online:

主页: https://www.nature.com/gt

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ILK promotes survival and self-renewal of hypoxic MSCs via the activation of lncTCF7-Wnt pathway induced by IL-6/STAT3 signaling

Regulated ex vivo regional gene therapy for bone repair using an inducible caspase-9 suicide gene system

Stability of the adeno-associated virus 8 reference standard material

Bat adeno-associated viruses as gene therapy vectors with the potential to evade human neutralizing antibodies

Safety and efficacy evaluations of an adeno-associated virus variant for preparing IL10-secreting human neural stem cell-based therapeutics

Magic realism: a Latin American paradigm for stem cell research & development?

scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor

Production of lentiviral vectors using novel, enzymatically produced, linear DNA

Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options

Measles vector as a multiple genes delivery platform facilitating iPSC reprogramming

Cell therapy for Parkinson′s disease is coming of age: current challenges and future prospects with a focus on immunomodulation

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury

Regulatable adenovector harboring the GFP and Yamanaka genes for implementing regenerative medicine in the brain

Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth

Adeno-associated virus neutralising antibodies in type 1 diabetes mellitus

Delivering cellular and gene therapies to patients: solutions for realizing the potential of the next generation of medicine

Inhibition of microRNA-495 suppresses chondrocyte apoptosis through activation of the NF-κB signaling pathway by regulating CCL4 in osteoarthritis

A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles

Factors governing the transduction efficiency of adeno-associated virus in the retinal ganglion cells following intravitreal injection

Safe and neuroprotective vectors for long-term traumatic brain injury gene therapy

Polarized AAVR expression determines infectivity by AAV gene therapy vectors

Dual-targeted NIS polyplexes—a theranostic strategy toward tumors with heterogeneous receptor expression

Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma

Helper-dependent adenovirus-mediated gene transfer of a secreted LDL receptor/transferrin chimeric protein reduces aortic atherosclerosis in LDL receptor-deficient mice

A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases

Evaluation of the Glypican 3 promoter for transcriptional targeting of hepatocellular carcinoma

In vitro evaluation of a lentiviral two-step transcriptional amplification system using GAL4FF transactivator for gene therapy applications in bone repair

Superior lentiviral vectors designed for BSL-0 environment abolish vector mobilization

Reviewer recognition

Histone deacetylase inhibitors reactivate silenced transgene in vivo

Improved therapeutic potential of MSCs by genetic modification

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression

Driving cars to the clinic for solid tumors

Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters

Effects of microRNA-292-5p on myocardial ischemia–reperfusion injury through the peroxisome proliferator-activated receptor-α/-γ signaling pathway

Stable and reproducible transgene expression independent of proliferative or differentiated state using BAC TG-EMBED

Characterization of a replicating expanded tropism oncolytic reovirus carrying the adenovirus E4orf4 gene

Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9

Effect of PAK1 gene silencing on proliferation and apoptosis in hepatocellular carcinoma cell lines MHCC97-H and HepG2 and cells in xenograft tumor

Long noncoding RNA Meg3 regulates cardiomyocyte apoptosis in myocardial infarction

MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates

Electroporation-mediated delivery of FER gene enhances innate immune response and improves survival in a murine model of pneumonia

Optimization of viral protein ratios for production of rAAV serotype 5 in the baculovirus system

In vivo delivery of pPERDBY to BALB/c mice by LacVax？ DNA-I and comparison of elicited immune response with conventional immunization methods

Anti-angiogenic treatment of endometriosis via anti-VEGFA siRNA delivery by means of peptide-based carrier in a rat subcutaneous model

Unilateral ex vivo gene therapy by GDNF in epileptic rats

Epistasis between Pax6Sey and genetic background reinforces the value of defined hybrid mouse models for therapeutic trials

Osteoinduction within BMP-2 transduced muscle tissue fragments with and without a fascia layer: implications for bone tissue engineering

Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy

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