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OALib Journal期刊
ISSN: 2333-9721
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ISSN Print: 1937-9145

ISSN Online:

主页: http://stke.sciencemag.org/content/by/year

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Tuning ITAM multiplicity on T cell receptors can control potency and selectivity to ligand density

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Inhibition of somatosensory mechanotransduction by annexin A6

A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner

Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites

Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment–sensing programs

Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity

Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity

Profiling the origin, dynamics, and function of traction force in B cell activation

Palmitoylation of δ-catenin promotes kinesin-mediated membrane trafficking of Na v1.6 in sensory neurons to promote neuropathic pain

Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis

Pin1 mediates Aβ 42-induced dendritic spine loss

Transient inflammatory signaling promotes beige adipogenesis

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters

Architecture of the complete oxygen-sensing FixL-FixJ two-component signal transduction system

SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract

Integration of protein phosphorylation, acetylation, and methylation data sets to outline lung cancer signaling networks

MEG3-4 is a miRNA decoy that regulates IL-1β abundance to initiate and then limit inflammation to prevent sepsis during lung infection

The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Nuclear import pathway key to rescuing dominant progerin phenotypes

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Aurora-PLK1 cascades as key signaling modules in the regulation of mitosis

Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia

Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis

Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain

Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology

Biased antagonism of CXCR4 avoids antagonist tolerance

G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation

Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

Should the clinic matter to nonphysician scientists?

The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury

Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential

A call to arms: Unifying the fight against resistance

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation

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