Background: Ameloblastoma is an odontogenic tumor that originates from epithelial cells. Despite its benign classification, it exhibits local aggressiveness and the potential for unlimited growth. The 2022 World Health Organization (WHO) classification identifies five distinct subtypes of ameloblastoma, each displaying varying biological behaviors. Plexiform ameloblastoma is a subtype of conventional ameloblastoma that is characterized by a unique histopathological appearance. Unlike the typical follicular or acanthomatous patterns, plexiform ameloblastomas exhibit a network of interconnected strands or cords of odontogenic epithelium that resemble a “plexus” or network. This paper aims to present two clinical cases of conventional plexiform ameloblastoma, provide a review of the current literature, and detail the clinical, radiological, and histopathological features of this condition, as well as appropriate therapeutic approaches. Case presentation: This article presents two cases of plexiform ameloblastoma, a prevalent subtype of ameloblastoma, with one arising in the maxilla and the other in the mandible. The cases are analyzed in the context of existing literature to shed light on the unique features and clinical implications of this subtype. Conclusion: Plexiform ameloblastoma is a rare and benign odontogenic tumor that may reach gigantic proportions. Thus, ensuring an accurate diagnosis is crucial to minimizing the risk of local recurrences and obtaining an effective treatment.
Cite this paper
Oumayma, E. Y. , Malik, B. , Hicham, B. and Bouchra, T. (2025). Plexiform Ameloblastoma: Report of 2 Cases and Review of Literature. Open Access Library Journal, 12, e2857. doi: http://dx.doi.org/10.4236/oalib.1112857.
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